QuickView for Ncor2 (gene)
- Gene Symbol:
- NCOR2
Homo sapiens - Full name:
- nuclear receptor corepressor 2
- Synonyms:
- CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2, CTG repeat protein 26, T3 receptor-associating factor, silencing mediator for retinoid and thyroid hormone receptors, thyroid-, retinoic-acid-receptor-associated corepressor
- Genomic Location:
- Chr 12: 123374914-123586102
- Description:
-
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q24.31
GO Molecular Function
RNA polymerase II transcription factor activity, sequence-specific DNA binding | hormone receptor binding | enzyme binding | nucleic acid binding | signaling receptor binding | Notch binding | protein N-terminus binding | DNA binding | transcription corepressor activity | nuclear hormone receptor binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | transcription factor binding | nuclear receptor binding | histone deacetylase binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | negative regulation of gene silencing by RNA | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter | cellular process | regulation of production of miRNAs involved in gene silencing by miRNA | negative regulation of nucleic acid-templated transcription | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | cellular nitrogen compound biosynthetic process | regulation of gene silencing | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | negative regulation of gene silencing by miRNA | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | negative regulation of gene silencing | DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of gene silencing by RNA | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | regulation of production of small RNA involved in gene silencing by RNA | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | negative regulation of transcription by RNA polymerase II | transcription coregulator activity | heterocycle metabolic process | regulation of lipid metabolic process | positive regulation of metabolic process | cellular metabolic process | positive regulation of gene expression | negative regulation of production of miRNAs involved in gene silencing by miRNA | macromolecule metabolic process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | intracellular organelle | nuclear body | protein-containing complex | histone deacetylase complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | membrane-enclosed lumen | nuclear matrix | nuclear chromatin | intracellular | membrane | nuclear periphery
