QuickView for Neuregulin 1 (gene)

Gene Symbol:

NRG1 Homo sapiens

Full name:

neuregulin 1

Synonyms:

ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF, pro-neuregulin-1, membrane-bound isoform, acetylcholine receptor-inducing activity, glial growth factor 2, heregulin, alpha (45kD, ERBB2 p185-activator), neu differentiation factor, pro-NRG1, sensory and motor neuron derived factor

Genomic Location:

Chr 8: 31616810-32741615

Description:

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific...

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The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  RTAAACA_FREAC2_01 ,  FREAC7_01 ,  SMTTTTGT_UNKNOWN ,  STAT4_01 ,  TGANTCA_AP1_C ,  ZIC1_01 ,  FOX_Q2 ,  P53_DECAMER_Q2 ,  TGANNYRGCA_TCF11MAFG_01 ,  ATGTCAC_MIR489 ,  FOXO4_01 ,  NKX3A_01 ,  GCANCTGNY_MYOD_Q6 ,  TGTGTGA_MIR377 ,  EVI1_04 ,  WGTTNNNNNAAA_UNKNOWN ,  ACTTTAT_MIR1425P ,  ZIC3_01 ,  CTTTGA_LEF1_Q2 ,  STAT1_03 ,  MYB_Q5_01 ,  TGACCTY_ERR1_Q2 ,  WHN_B ,  GGGAGGRR_MAZ_Q6 ,  GTGTGAG_MIR342 ,  CDPCR3HD_01 ,  GGTGTGT_MIR329 ,  CACCCBINDINGFACTOR_Q6 ,  FOXO3_01 ,  CAGGTA_AREB6_01 ,  FREAC3_01 ,  RREB1_01 ,  P53_02 ,  CAGGTG_E12_Q6 ,  PXR_Q2 ,  HNF3_Q6 ,  FOXJ2_01 ,  TGCTGAY_UNKNOWN ,  ACTGCCT_MIR34B ,  AHR_Q5 ,  FOXO1_01 ,  HFH4_01 ,  MEIS1_01 ,  TGTTTGY_HNF3_Q6 ,  PAX8_B ,  RNGTGGGC_UNKNOWN ,  EN1_01 ,  FREAC2_01 ,  AP2_Q6 ,  HAND1E47_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  AP2REP_01 ,  AAAYRNCTG_UNKNOWN ,  HEN1_02 ,  PAX5_01 ,  CTGCAGY_UNKNOWN ,  PAX_Q6 ,  TGACAGNY_MEIS1_01 ,  GRE_C ,  CTTTGT_LEF1_Q2 ,  LXR_Q3 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  DR4_Q2 ,  ETS1_B ,  STTTCRNTTT_IRF_Q6 ,  FOXO4_02 ,  HNF6_Q6 ,  GGGTGGRR_PAX4_03 ,  TCF11_01

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Cytogenetic Map:

8p12

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