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QuickView for NeuroD2 (gene)


Gene Symbol:
NEUROD2 Homo sapiens Homo sapiens
Full name:
neuronal differentiation 2
Synonyms:
NDRF, bHLHa1, neurogenic differentiation factor 2, class A basic helix-loop-helix protein 1, neuroD-related factor, neurogenic basic-helix-loop-helix protein, neurogenic differentiation 2
Genomic Location:
Chr 17: 35013547-35017701
Description:
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuron...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CGTSACG_PAX3_B GATTGGY_NFY_Q6_01 NFMUE1_Q6 FREAC7_01 HNF3ALPHA_Q6 MAZR_01 TAL1ALPHAE47_01 TCANNTGAY_SREBP1_01 ARNT_01 TGGNNNNNNKCCAR_UNKNOWN
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q12


Transcripts Names
NM_006160
Protein Names
Q9UQC6
Q8TBI7
Q15784



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | E-box binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription coregulator activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | brain development | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | regulation of neurogenesis | behavioral fear response | regulation of cell development | positive regulation of DNA-binding transcription factor activity | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | response to metal ion | cell differentiation | defense response | nervous system development | neurogenesis | generation of neurons | positive regulation of cellular biosynthetic process | cellular process | regulation of calcium-mediated signaling | negative regulation of synapse organization | neuron development | negative regulation of nucleic acid-templated transcription | learning | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular response to metal ion | head development | associative learning | response to stimulus | metencephalon development | response to stress | cellular nitrogen compound biosynthetic process | positive regulation of synaptic plasticity | cellular response to inorganic substance | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | regulation of synapse structure or activity | modulation of chemical synaptic transmission | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | learning or memory | cerebellum development | regulation of neuron differentiation | regulation of gene expression | nervous system process | positive regulation of cellular metabolic process | regulation of synapse maturation | regulation of synapse organization | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | positive regulation of intracellular signal transduction | transcription corepressor activity | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | positive regulation of calcium-mediated signaling | cognition | biosynthetic process | aromatic compound biosynthetic process | hindbrain development | negative regulation of synapse maturation | regulation of cellular metabolic process | positive regulation of synapse maturation | positive regulation of signal transduction | regulation of RNA metabolic process | positive regulation of molecular function | neuron differentiation | multicellular organismal response to stress | fear response | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | cellular response to calcium ion | protein ubiquitination | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | regulation of RNA biosynthetic process | cerebellar cortex development | behavior | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | animal organ development | gene expression | protein modification by small protein conjugation or removal | transcription, DNA-templated | regulation of cell communication | regulation of transcription, DNA-templated | cell development | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of nervous system development | regulation of developmental process | developmental process | behavioral defense response | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | cellular response to electrical stimulus | heterocycle metabolic process | response to electrical stimulus | response to calcium ion | central nervous system development | positive regulation of metabolic process | regulation of synaptic plasticity | positive regulation of neuron differentiation | cellular metabolic process | regulation of cellular component organization | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular