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QuickView for Neutrophil elastase (gene)


Gene Symbol:
ELANE Homo sapiens Homo sapiens
Full name:
elastase, neutrophil expressed
Synonyms:
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1, neutrophil elastase, PMN elastase, bone marrow serine protease, elastase 2, neutrophil, elastase-2, granulocyte-derived elastase, leukocyte elastase, medullasin, polymorphonuclear elastase
Genomic Location:
Chr 19: 803291-807246
Description:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil l...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 19
19p13.3


Transcripts Names
NM_001972
XM_011527775
XM_011527776
Protein Names
P09649
Q6LDP5
Q6B0D9
P08246



GO Molecular Function

cytokine binding | enzyme binding | hydrolase activity | carbohydrate derivative binding | catalytic activity | serine hydrolase activity | anion binding | transcription corepressor activity | ion binding | heparin binding | protein binding | glycosaminoglycan binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | protease binding | transcription coregulator activity | peptidase activity

GO Biological Process

positive regulation of immune response | positive regulation of smooth muscle cell proliferation | response to radiation | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | positive regulation of leukocyte adhesion to vascular endothelial cell | exocytosis | extracellular structure organization | positive regulation of leukocyte tethering or rolling | cell motility | neutrophil activation | response to lipopolysaccharide | neutrophil mediated killing of bacterium | proteolysis | regulation of localization | defense response to other organism | establishment of localization | regulation of immune system process | negative regulation of cellular process | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | negative regulation of growth of symbiont involved in interaction with host | defense response | cellular chemical homeostasis | killing by host of symbiont cells | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | defense response to Gram-negative bacterium | interaction with symbiont | positive regulation of cellular biosynthetic process | cellular process | secretion | organic substance catabolic process | negative regulation of inflammatory response | leukocyte degranulation | regulation of cytokine biosynthetic process | regulation of cell motility | localization | cellular homeostasis | antibacterial peptide production | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | regulation of chemotaxis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | interspecies interaction between organisms | response to yeast | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | catabolic process | negative regulation of chemotaxis | regulation of cellular extravasation | positive regulation of cellular protein metabolic process | cellular component organization | calcium ion homeostasis | response to UV | response to stimulus | defense response to fungus | peptide biosynthetic process | neutrophil degranulation | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of cell-cell adhesion | inflammatory response to antigenic stimulus | positive regulation of cytokine biosynthetic process | secretion by cell | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | extracellular matrix organization | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | regulation of cell adhesion | cellular biosynthetic process | metal ion homeostasis | leukocyte migration | regulation of nucleic acid-templated transcription | locomotion | antibacterial peptide biosynthetic process | response to light stimulus | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | regulation of interleukin-8 biosynthetic process | negative regulation of growth | biosynthetic process of antibacterial peptides active against Gram-negative bacteria | neutrophil mediated killing of fungus | cell migration | antibacterial humoral response | regulation of MAPK cascade | leukocyte mediated immunity | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | cell killing | negative regulation of chemokine production | response to lipid | protein catabolic process | modification of morphology or physiology of other organism | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of intracellular signal transduction | transcription corepressor activity | cellular amide metabolic process | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of cell migration | biosynthetic process | regulation of cellular protein metabolic process | regulated exocytosis | cation homeostasis | regulation of leukocyte migration | positive regulation of cellular extravasation | negative regulation of cytokine biosynthetic process | response to bacterium | response to fungus | cellular cation homeostasis | regulation of cellular metabolic process | regulation of protein kinase activity | antimicrobial humoral immune response mediated by antimicrobial peptide | humoral immune response | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | cellular calcium ion homeostasis | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | peptide metabolic process | regulation of locomotion | regulation of RNA metabolic process | positive regulation of molecular function | acute inflammatory response to antigenic stimulus | disruption by host of symbiont cells | antimicrobial humoral response | protein metabolic process | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of kinase activity | import into cell | killing of cells of other organism | regulation of intracellular signal transduction | metabolic process | negative regulation of interleukin-8 biosynthetic process | negative regulation of growth of symbiont in host | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | chemical homeostasis | endocytosis | immune response | leukocyte mediated cytotoxicity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | amide biosynthetic process | positive regulation of leukocyte migration | positive regulation of kinase activity | ion homeostasis | serine-type endopeptidase activity | regulation of phosphate metabolic process | serine-type peptidase activity | negative regulation of interleukin-8 production | positive regulation of cytokine production | cell activation | positive regulation of MAPK cascade | leukocyte migration involved in inflammatory response | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of cell communication | regulation of transcription, DNA-templated | endopeptidase activity | positive regulation of phosphorylation | regulation of cytokine production | positive regulation of MAP kinase activity | response to biotic stimulus | neutrophil mediated killing of gram-negative bacterium | regulation of chemokine production | negative regulation of transcription by RNA polymerase II | regulation of cell-cell adhesion | neutrophil mediated immunity | transcription coregulator activity | cellular metal ion homeostasis | positive regulation of metabolic process | positive regulation of interleukin-8 biosynthetic process | acute inflammatory response | immune system process | cellular metabolic process | peptidase activity | regulation of smooth muscle cell proliferation | positive regulation of cell motility | negative regulation of chemokine biosynthetic process | regulation of inflammatory response | divalent inorganic cation homeostasis | negative regulation of locomotion | phagocytosis | positive regulation of leukocyte cell-cell adhesion | extracellular matrix disassembly | response to other organism | positive regulation of signaling | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | protein-containing complex | secretory vesicle | endomembrane system | vacuole | vesicle | extracellular exosome | specific granule | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | specific granule lumen | transcriptional repressor complex | organelle | lysosome | extracellular space | membrane-enclosed lumen | azurophil granule | secretory granule lumen | intracellular vesicle | cell surface | intracellular | vesicle lumen