QuickView for Nfatc (gene)
- Gene Symbol:
- NFATC1
Homo sapiens - Full name:
- nuclear factor of activated T cells 1
- Synonyms:
- NF-ATC, NF-ATc1.2, NFAT2, NFATc, nuclear factor of activated T-cells, cytoplasmic 1, NFAT transcription complex cytosolic component, nuclear factor of activated T-cells 'c', nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
- Genomic Location:
- Chr 18: 75256760-75390311
- Description:
-
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of tr...
- Orthologs:
- Mus musculus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio , Rattus norvegicus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
18q23
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | FK506 binding | enhancer binding | protein kinase binding | proximal promoter sequence-specific DNA binding | mitogen-activated protein kinase p38 binding | enzyme binding | mitogen-activated protein kinase binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | transcription coactivator binding | chromatin binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | drug binding | transcription cofactor binding | heterocyclic compound binding | RNA polymerase II transcription coactivator binding | macrolide binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | immune response-regulating signaling pathway | intracellular signal transduction | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | inositol phosphate-mediated signaling | positive regulation of cellular biosynthetic process | cellular process | negative regulation of signaling | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | regulation of immune response | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of vasculature development | response to stimulus | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | regulation of gene expression | positive regulation of cellular metabolic process | regulation of smooth muscle cell differentiation | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | Fc-epsilon receptor signaling pathway | second-messenger-mediated signaling | non-canonical Wnt signaling pathway | negative regulation of smooth muscle cell differentiation | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | calcium-mediated signaling | cytokine production | Wnt signaling pathway, calcium modulating pathway | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of Wnt signaling pathway | calcineurin-mediated signaling | negative regulation of vascular smooth muscle cell differentiation | calcineurin-NFAT signaling cascade | transcription, DNA-templated | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | regulation of developmental process | regulation of muscle cell differentiation | Fc receptor signaling pathway | positive regulation of transcription, DNA-templated | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | negative regulation of muscle cell differentiation | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | cellular metabolic process | negative regulation of cell differentiation | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
nuclear transcription factor complex | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular
