Name: | Niacin |
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PubChem Compound ID: | 16098 |
Description: | A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. |
Molecular formula: | C18H12AlN3O6 |
Molecular weight: | 393.286 g/mol |
Synonyms: |
3-Pyridinecarboxylic acid, aluminum salt; Aluminum 3-pyridinecarboxylate; 59-67-6; Nicotinic acid, aluminum salt; 1976-28-9; Aluminum, tris(nicotinato)-; Tris(nicotinato)aluminum; Aluminum nicotinate; Aluminium trinicotinate; EINECS 217-832-7.
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Name: | Niacin |
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Name (isomeric): | DB00627 |
Drug Type: | small molecule |
Description: | A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. |
Synonyms: |
Pyridinecarboxylic Acid; Nicotine Acid; Vitamin B3; 3-Pyridinecarboxylic acid; NAH; Nicotinic Acid; M-Pyridinecarboxylic Acid; Pyridylcarboxylic Acid; Acide Nicotinique; Acidum Nicotinicum
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Brand: | Pellagramin, Nicosyl, Pellagrin, Nicocidin, Niaspan, Nipellen, Efacin, Nyclin, Nicodelmine, Vitaplex N, Kyselina Nikotinova, Nicotamin, Linic, Akotin, Nicyl, Sk-Niacin, PP Factor, Nicodon, Direktan, Nicocrisina, Nicodan, Bionic, Nicotene, P.P. Factor, Tinic, Nicosan 3, Nicangin, Nicotil, Diacin, Niconazid, Nicovel, Naotin, Nicovasen, Nicacid, Nicovasan, Nico-Span, Nicorol, Pellagra Preventive Factor, Daskil, Nicoside, NICO, Niconat, Nicotinsaure, Anti-Pellagra Vitamin, Niac, Peviton, Nicotinipca, Apelagrin, Simcor, Tega-Span, Davitamon PP, Niconacid, Pelonin |
Brand name mixture: | Niacin Capsules with Chromium(Chromium + Nicotinic Acid), My Favorite Niacin and Inositol Tab(Inositol + Nicotinic Acid), Vitamin C with Niacin and Niacinamide-Liq(Nicotinamide + Nicotinic Acid + Vitamin C), One a Day Advance High Pot.B Complex and C(Beta-Carotene + Copper (Cupric Oxide) + D-Pantothenic Acid (Calcium D-Pantothenate) + Dl-Alpha T... show more » |
Category: | Vasodilator Agents, Vitamin B Complex, Antilipemic Agents, Vitamins (Vitamin B Complex) |
CAS number: | 59-67-6 |
Indication: | For the treatment of type IV and V hyperlipidemia. It is indicated as ajunctive therapy. |
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Pharmacology: |
Niacin and niacinamide are indicated for prevention and treatment of vitamin B3 deficiency states. Vitamin B3 (Niacin) also acts to reduce LDL cholesterol, triglycerides, and HDL cholesterol. The magnitude of individual lipid and lipoprotein responses may be influenced by the severity and type of underlying lipid abnormality. The increase in total ...
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Mechanism of Action: |
Niacin binds to Nicotinate D-ribonucleotide phyrophsopate phosphoribosyltransferase, Nicotinic acid phosphoribosyltransferase, Nicotinate N-methyltransferase and the Niacin receptor. Niacin is the precursor to nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are vital cofactors for dozens of enzy...
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Absorption: | Both nicotinic acid and nicotinamide are efficiently absorbed from the stomach and small intestine. |
Biotransformation: | Hepatic |
Half Life: | 20-45 minutes. |
Toxicity: | Nicotinic acid can cause vasodilation of cutaneous blood vessels resulting in increased blood flow, principally in the face, neck and chest. This produces the niacin- or nicotinic acid-flush. The niacin-flush is thought to be mediated via the prostaglandin prostacyclin. Histamine may also play a role in the niacin-flush. Flushing is the adverse reaction first observed after intake of a large dose of nicotinic acid, and the most bothersome one. LD50 7000 mg/kg (Rat) |
Affected organisms: | Humans and other mammals |
Food interaction: |
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