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QuickView for Nitrazepam (compound)
PubChem
| Name: | Nitrazepam |
|---|---|
| PubChem Compound ID: | 4506 |
| Description: | A benzodiazepine derivative used as an anticonvulsant and hypnotic. |
| Molecular formula: | C15H11N3O3 |
| Molecular weight: | 281.266 g/mol |
| Synonyms: |
Benzalin; Paxisyn; Megadon; Dormicum; Eunoctin; Hipnax; LA 1 (VAN); NSC-58775; Imeson; Nitrados.
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DrugBank
Identification
| Name: | Nitrazepam |
|---|---|
| Name (isomeric): | DB01595 |
| Drug Type: | small molecule |
| Description: | A benzodiazepine derivative used as an anticonvulsant and hypnotic. |
| Synonyms: |
N-desmethylnimetazepam; 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; Nitrazepamum [inn-latin]; NTZ; 7-Nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on; 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 1, 3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
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| Brand: | Sonnolin, Sandoz nitrazepam, Nelmat, Dormicum, Somnibel, Nitrazepam-10, Calsamin, Ipersed, Unisomnia, Nitrenpax, Dormo-puren, Nitrempax, Imesont, Epibenzalin, Dormin-5, Remnos, Noctesed, Magadon, Surem, Atempol, Nitrazepam-5, Somnite, Trazenin, Somnased, Somitran, Insomin, Eunoctin, Benzalin, Nitrados, Nitrazadon, Sonebon, Hipsal, Ibrovek, Epinelbon, Mogadon, Persopit, Pacisyn, Pelson, Imeson, Mogadan, Eatan n, Alodorm, Apo-nitrazepam tablets BP, Nelbon, Neozepam, Calsmin, Eunoktin, LA 1 (VAN), Hipnax, Nitravet, Relact, Paxisyn, Cerson, Mitidin, Sonebon tofraniln a, Gerson, Eatan, Apodorm, Megadon, Mogadone, Neuchlonic, Dumolid, Radedorm |
| Category: | Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives, Anticonvulsants |
| CAS number: | 146-22-5 |
Pharmacology
| Indication: | Used to treat short-term sleeping problems (insomnia), such as difficulty falling asleep, frequent awakenings during the night, and early-morning awakening. |
|---|---|
| Pharmacology: | Nitrazepam is a type of benzodiazepine drug. It is a powerful hypnotic drug which possesses strong sedative, anxiolytic, amnestic, anticonvulsant, and skeletal muscle relaxant properties. Nitrazepam shortens the time required to fall asleep and lengthens the duration of sleep. It is also useful for the management of myoclonic seizures. |
| Mechanism of Action: |
Nitrazepam belongs to a group of medicines called benzodiazepines. It acts on benzodiazepine receptors in the brain which are associated with the GABA receptors causing an enhanced binding of GABA (gamma amino butyric acid) to GABAA receptors. GABA is a major inhibitory neurotransmitter in the brain, involved in inducing sleepiness, muscular relaxa...
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| Absorption: | Bioavailability is 53-94% following oral administration. |
| Half Life: | 15-38 hours (mean elimination half life 26 hours). |
| Toxicity: | Nitrazepam is a drug which is very frequently involved in drug intoxication, including overdose. Nitrazepam overdose may result in stereotypical symptoms of benzodiazepine overdose including intoxication, impaired balance, slurred speech. In cases of severe overdose this may progress to a comatose state with the possibility of death. |
| Affected organisms: | Humans and other mammals |
Interactions
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Targets
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