Name: | Nitrendipine |
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PubChem Compound ID: | 10893799 |
Description: | A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. |
Molecular formula: | C18H20N2O6 |
Molecular weight: | 362.369 g/mol |
Name: | Nitrendipine |
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Name (isomeric): | DB01054 |
Drug Type: | small molecule |
Description: | A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. |
Synonyms: |
Nitrendipinum [INN-Latin]; Nitrendipino [INN-Spanish]; Nitrendipin
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Brand: | Nidrel, Baypress, Nitrepin, Bylotensin, Bayotensin, Deiten |
Category: | Vasodilator Agents, Calcium Channel Blockers, Antihypertensive Agents |
CAS number: | 39562-70-4 |
Indication: | For the treatment of mild to moderate hypertension |
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Pharmacology: |
Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Nitrendipine is similar to other peripheral vasodilators. Nitrendipine inhibits the influx of extra cellular calcium across the myocardial ...
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Mechanism of Action: |
By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the ...
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Protein binding: | > 99% |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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