QuickView for Nkx3 (gene)
- Gene Symbol:
- NKX3-1
Homo sapiens - Full name:
- NK3 homeobox 1
- Synonyms:
- BAPX2, NKX3, NKX3.1, NKX3A, homeobox protein Nkx-3.1, NK homeobox, family 3, A, NK3 transcription factor homolog A, NK3 transcription factor related, locus 1, homeobox protein NK-3 homolog A
- Genomic Location:
- Chr 8: 23592173-23596395
- Description:
-
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Danio rerio , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
8p21.2
GO Molecular Function
sequence-specific DNA binding | protein kinase activator activity | protein self-association | MADS box domain binding | enzyme activator activity | protein kinase regulator activity | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | hormone receptor binding | kinase regulator activity | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | peptidase activator activity | estrogen receptor binding | signaling receptor binding | steroid hormone receptor activity | molecular function regulator | protein domain specific binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | peptidase activator activity involved in apoptotic process | nuclear hormone receptor binding | androgen receptor activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | estrogen receptor activity | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | kinase activator activity | RNA polymerase II regulatory region sequence-specific DNA binding | cysteine-type endopeptidase regulator activity involved in apoptotic process | enzyme regulator activity | steroid hormone receptor binding | cysteine-type endopeptidase activator activity involved in apoptotic process | histone deacetylase binding | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | protein kinase activator activity | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to cytokine | response to interleukin-1 | pharyngeal system development | developmental process involved in reproduction | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | regulation of localization | protein kinase regulator activity | regulation of epithelial cell proliferation involved in prostate gland development | morphogenesis of an epithelium | gonad development | regulation of programmed cell death | response to hormone | dorsal aorta development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cellular response to tumor necrosis factor | positive regulation of intrinsic apoptotic signaling pathway | response to drug | androgen receptor signaling pathway | positive regulation of phosphate metabolic process | salivary gland morphogenesis | regulation of lipid transport | hormone-mediated signaling pathway | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | epithelial tube morphogenesis | negative regulation of signaling | kinase regulator activity | reproductive system development | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | response to hypoxia | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | peptidase activator activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | negative regulation of receptor binding | positive regulation of response to DNA damage stimulus | prostate gland epithelium morphogenesis | regulation of cell division | urogenital system development | development of primary sexual characteristics | negative regulation of insulin-like growth factor receptor signaling pathway | response to stimulus | vasculature development | positive regulation of protein metabolic process | positive regulation of peptidase activity | positive regulation of phosphatidylinositol 3-kinase signaling | cellular response to hypoxia | gland morphogenesis | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | positive regulation of cysteine-type endopeptidase activity | programmed cell death | reproduction | cardiovascular system development | positive regulation of proteolysis | cellular nitrogen compound metabolic process | positive regulation of hormone secretion | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | kidney development | embryo development | activation of protein kinase activity | molecular function regulator | blood vessel development | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | protein kinase B signaling | cellular response to hormone stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | multicellular organism development | regulation of peptidase activity | regulation of catalytic activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | regulation of hormone levels | regulation of hormone secretion | artery development | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | positive regulation of secretion | response to ketone | cellular response to stress | response to lipid | cell cycle | branching involved in prostate gland morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | peptidase activator activity involved in apoptotic process | negative regulation of binding | positive regulation of hydrolase activity | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of endopeptidase activity | androgen receptor activity | positive regulation of lipid localization | regulation of apoptotic signaling pathway | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | cellular response to drug | chordate embryonic development | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | response to testosterone | metanephros development | regulation of endocrine process | regulation of protein metabolic process | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | regulation of protein phosphorylation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | positive regulation of transport | estrogen receptor activity | regulation of mitotic cell cycle | positive regulation of molecular function | development of primary male sexual characteristics | negative regulation of epithelial cell proliferation | DNA-binding transcription factor activity | regionalization | positive regulation of protein modification process | response to organic substance | gland development | tissue morphogenesis | cell cycle arrest | regulation of insulin-like growth factor receptor signaling pathway | branching morphogenesis of an epithelial tube | epithelial cell proliferation | regulation of kinase activity | male sex differentiation | regulation of intracellular signal transduction | anatomical structure development | kinase activator activity | aorta development | metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | male gonad development | negative regulation of mitotic cell cycle | regulation of secretion | positive regulation of cell death | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of phosphate metabolic process | cellular response to steroid hormone stimulus | prostate gland morphogenesis | transcription, DNA-templated | intracellular receptor signaling pathway | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | regulation of cell communication | cysteine-type endopeptidase regulator activity involved in apoptotic process | negative regulation of molecular function | negative regulation of signal transduction | signaling | somite development | mitotic cell cycle arrest | regulation of transcription, DNA-templated | regulation of protein binding | response to organic cyclic compound | regulation of epithelial cell proliferation | positive regulation of phosphorylation | enzyme regulator activity | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | reproductive structure development | regulation of developmental process | epithelial cell proliferation involved in salivary gland morphogenesis | segmentation | developmental process | cellular response to interleukin-1 | negative regulation of estrogen receptor binding | intracellular steroid hormone receptor signaling pathway | tube development | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | cysteine-type endopeptidase activator activity involved in apoptotic process | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | somitogenesis | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding | positive regulation of metabolic process | positive regulation of lipid transport | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | exocrine system development | regulation of cell death | sex differentiation | salivary gland development | response to steroid hormone | negative regulation of epithelial cell proliferation involved in prostate gland development | circulatory system development | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | positive regulation of androgen secretion | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
