Name: | norelgestromin |
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PubChem Compound ID: | 9568628 |
Molecular formula: | C21H29NO2 |
Molecular weight: | 327.461 g/mol |
Name: | norelgestromin |
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Name (isomeric): | DB06713 |
Drug Type: | small molecule |
Brand: | Orthra Evra |
Brand name mixture: | Ortho Evra(Norelgestromin 6mg, ethinyl estradiol 0.75gm) |
Category: | Contraceptive Agents, Female, Contraceptives |
CAS number: | 53016-31-2 |
Indication: | Norelgestromin is used for contraception and menopausal hormonal therapy. Norelgestromin may potentially be used in breast cancer treatment due to its inhibitory effect on estrone sulfatase . They convert sulfated steroid precursors to estrogen during pregnancy. |
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Pharmacology: | Norelgestromin is used for contraception and menopausal hormonal therapy transdermally or in combination with ethinyl estradiol as a vaginal ring. Norelgestromin, in combination with ethinyl estradiol inhibits ovulation by suppressing gonadotropins. |
Mechanism of Action: |
Norelgestromin inhibits estrone sulfatase, which converts sulfated steroid precursors to estrogen during pregnancy. Norgelgestromin/ethinylestradiol suppresses follicular development, induces changes to the endometrium, which decreases chances of implantation and thickens the cervical mucus, impeding sperm swimming into the uterus. It also has simi...
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Drug interaction: |
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