QuickView for Nr4a1 (gene)
- Gene Symbol:
- NR4A1
Homo sapiens - Full name:
- nuclear receptor subfamily 4 group A member 1
- Synonyms:
- GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3, nuclear receptor subfamily 4 group A member 1, ST-59, TR3 orphan receptor, early response protein NAK1, growth factor-inducible nuclear protein N10, hormone receptor, nerve growth factor IB nuclear receptor variant 1, nuclear hormone receptor NUR/77, orphan nuclear receptor HMR, orphan nuclear receptor TR3, steroid receptor TR3, testicular receptor 3
- Genomic Location:
- Chr 12: 50731458-50739554
- Description:
-
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multi...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Danio rerio , Pan troglodytes , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q13.13
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | cation binding | hormone receptor binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | nuclear hormone receptor binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | steroid hormone receptor binding | metal ion binding | glucocorticoid receptor binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | cell motility | blood vessel endothelial cell migration | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cell differentiation | positive regulation of epithelial cell proliferation | epithelial cell migration | positive regulation of endothelial cell proliferation | hormone-mediated signaling pathway | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | localization | epithelium migration | transcription factor activity, direct ligand regulated sequence-specific DNA binding | regulation of cell cycle | response to growth factor | positive regulation of nitrogen compound metabolic process | response to peptide hormone | regulation of cellular process | cellular response to lipid | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | sprouting angiogenesis | response to stimulus | vasculature development | cellular response to vascular endothelial growth factor stimulus | cellular response to fibroblast growth factor stimulus | endothelial cell migration | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | response to peptide | cardiovascular system development | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of RNA biosynthetic process | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | cell chemotaxis | blood vessel development | regulation of nucleic acid-templated transcription | locomotion | response to nitrogen compound | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | multicellular organism development | cell migration | cellular response to peptide hormone stimulus | regulation of gene expression | response to lipid | cellular response to peptide | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | fat cell differentiation | biosynthetic process | aromatic compound biosynthetic process | angiogenesis | cell communication | regulation of cellular metabolic process | positive regulation of cell proliferation | regulation of RNA metabolic process | cellular response to corticotropin-releasing hormone stimulus | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | endothelial cell chemotaxis | DNA-binding transcription factor activity | response to organic substance | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of endothelial cell proliferation | gene expression | response to corticotropin-releasing hormone | cellular response to steroid hormone stimulus | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of epithelial cell proliferation | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | developmental process | tube development | positive regulation of transcription, DNA-templated | cell migration involved in sprouting angiogenesis | response to fibroblast growth factor | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | regulation of type B pancreatic cell proliferation | cellular metabolic process | ameboidal-type cell migration | cellular response to organic substance | response to steroid hormone | circulatory system development | chemotaxis | signal transduction | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | nucleoplasm | nuclear envelope | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular | membrane
