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QuickView for Nrdp1 (gene)


Gene Symbol:
RNF41 Homo sapiens Homo sapiens
Full name:
ring finger protein 41
Synonyms:
FLRF, NRDP1, SBBI03, E3 ubiquitin-protein ligase NRDP1, RING-type E3 ubiquitin transferase NRDP1, fetal liver ring finger, neuregulin receptor degradation protein-1, ring finger protein 41, E3 ubiquitin protein ligase
Genomic Location:
Chr 12: 54884552-54902002
Description:
This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12
12q13.3





GO Molecular Function

kinase binding | GTPase binding | interleukin-3 receptor binding | cation binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | signaling receptor binding | cytokine receptor binding | Ral GTPase binding | Ras GTPase binding | catalytic activity | protein domain specific binding | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | ion binding | protein tyrosine kinase binding | protein binding | zinc ion binding | erythropoietin receptor binding | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | small GTPase binding | ubiquitin-like protein ligase activity | growth factor receptor binding | metal ion binding

GO Biological Process

proteolysis | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of autophagy | regulation of immune system process | negative regulation of cellular process | negative regulation of mitochondrion organization | positive regulation of protein catabolic process | regulation of organelle organization | cellular process | organic substance catabolic process | regulation of cell motility | extrinsic apoptotic signaling pathway | proteolysis involved in cellular protein catabolic process | negative regulation of macroautophagy | positive regulation of reactive oxygen species metabolic process | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | negative regulation of cellular metabolic process | regulation of cell differentiation | negative regulation of cell motility | regulation of protein kinase B signaling | regulation of cellular process | regulation of metabolic process | catabolic process | regulation of establishment of cell polarity | response to stimulus | positive regulation of protein metabolic process | regulation of cell proliferation | programmed cell death | cellular protein catabolic process | proteasomal protein catabolic process | regulation of macroautophagy | negative regulation of metabolic process | protein modification process | macromolecule modification | negative regulation of autophagy of mitochondrion | regulation of lymphocyte differentiation | regulation of establishment or maintenance of cell polarity | regulation of nucleic acid-templated transcription | apoptotic process | negative regulation of mitophagy | nitrogen compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | regulation of phosphorylation | regulation of gene expression | protein catabolic process | positive regulation of cellular metabolic process | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cell migration | regulation of cellular component movement | ubiquitin protein ligase activity | regulation of cellular protein metabolic process | autophagy | negative regulation of autophagy | regulation of mitochondrion organization | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | apoptotic signaling pathway | regulation of autophagy of mitochondrion | positive regulation of molecular function | protein polyubiquitination | protein metabolic process | protein ubiquitination | regulation of hemopoiesis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cellular macromolecule catabolic process | protein autoubiquitination | cell surface receptor signaling pathway | metabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of RNA biosynthetic process | organic substance metabolic process | cell death | regulation of cell activation | negative regulation of cellular component movement | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | organonitrogen compound catabolic process | regulation of cell communication | signaling | regulation of transcription, DNA-templated | cellular protein metabolic process | regulation of developmental process | cellular protein modification process | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | positive regulation of metabolic process | cellular metabolic process | negative regulation of locomotion | regulation of cellular component organization | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | endomembrane system | perinuclear region of cytoplasm | membrane-bounded organelle | organelle | endoplasmic reticulum tubular network | cytosol | intracellular