QuickView for Ntcp (gene)

Gene Symbol:

SLC10A1 Homo sapiens

Full name:

solute carrier family 10 member 1

Synonyms:

NTCP, sodium/bile acid cotransporter, Na(+)/bile acid cotransporter, Na(+)/taurocholate transport protein, Na/taurocholate cotransporting polypeptide, cell growth-inhibiting gene 29 protein, growth-inhibiting protein 29, sodium/taurocholate cotransporter, sodium/taurocholate cotransporting polypeptide, solute carrier family 10 (sodium/bile acid cotransporter family), member 1, solute carrier family 10 (sodium/bile acid cotransporter), member 1

Genomic Location:

Chr 14: 69312305-69333707

Description:

The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that a...

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The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMTTTTGT_UNKNOWN ,  AACTTT_UNKNOWN

Cytogenetic Map:

14q24.1

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