QuickView for Nup96 (gene)

Gene Symbol:

NUP98 Homo sapiens

Full name:

nucleoporin 98

Synonyms:

ADIR2, NUP196, NUP96, nuclear pore complex protein Nup98-Nup96, nuclear pore complex protein Nup98, GLFG-repeat containing nucleoporin, NUP98/PHF23 fusion 2 protein, Nup98-Nup96, nucleoporin 98kD, nucleoporin 98kDa

Genomic Location:

Chr 11: 3652816-3775468

Description:

Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa...

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Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  NFY_C ,  ATF4_Q2 ,  AREB6_04 ,  CREB_Q4 ,  TGAYRTCA_ATF3_Q6 ,  GTGACGY_E4F1_Q6 ,  YYCATTCAWW_UNKNOWN ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TTCYRGAA_UNKNOWN ,  CREB_02 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  HIF1_Q5 ,  CREB_Q2 ,  TGACGTCA_ATF3_Q6 ,  CTTTGT_LEF1_Q2 ,  HIF1_Q3 ,  CREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-496

Cytogenetic Map:

11p15.4

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