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QuickView for OGDH (gene)


Gene Symbol:
OGDH Homo sapiens Homo sapiens
Full name:
oxoglutarate dehydrogenase
Synonyms:
AKGDH, E1k, OGDC, 2-oxoglutarate dehydrogenase, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide), oxoglutarate decarboxylase, oxoglutarate dehydrogenase (succinyl-transferring), testicular tissue protein Li 131
Genomic Location:
Chr 7: 44612696-44715194
Description:
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7p13





GO Molecular Function

thiamine pyrophosphate binding | cofactor binding | cation binding | vitamin binding | coenzyme binding | catalytic activity | chaperone binding | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | anion binding | ion binding | organic cyclic compound binding | protein binding | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | oxoglutarate dehydrogenase (succinyl-transferring) activity | heat shock protein binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | oxoglutarate dehydrogenase (NAD+) activity | small molecule binding

GO Biological Process

brain development | purine ribonucleotide metabolic process | purine ribonucleoside monophosphate biosynthetic process | cell motility | nucleoside phosphate catabolic process | tricarboxylic acid cycle | glycolytic process | sulfur compound metabolic process | subpallium development | hippocampus development | cell differentiation | nervous system development | nicotinamide nucleotide biosynthetic process | generation of precursor metabolites and energy | organophosphate catabolic process | neurogenesis | aerobic respiration | generation of neurons | tangential migration from the subventricular zone to the olfactory bulb | cellular process | organic substance catabolic process | localization | dicarboxylic acid metabolic process | forebrain cell migration | nucleotide metabolic process | neuron development | central nervous system neuron differentiation | cellular respiration | ribose phosphate metabolic process | purine nucleotide biosynthetic process | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | carbohydrate catabolic process | forebrain neuron differentiation | diencephalon development | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | succinyl-CoA metabolic process | head development | purine nucleotide metabolic process | monocarboxylic acid metabolic process | metencephalon development | cellular nitrogen compound biosynthetic process | telencephalon cell migration | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cofactor metabolic process | protein modification process | cellular biosynthetic process | macromolecule modification | nucleobase-containing compound catabolic process | pyramidal neuron development | nucleotide biosynthetic process | locomotion | central nervous system neuron development | NADH metabolic process | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | system development | ATP biosynthetic process | nitrogen compound metabolic process | coenzyme biosynthetic process | multicellular organism development | cell migration | antibiotic metabolic process | thalamus development | phosphorus metabolic process | ribonucleoside monophosphate biosynthetic process | acyl-CoA metabolic process | cerebellum development | forebrain neuron development | telencephalon development | organophosphate metabolic process | nucleotide phosphorylation | cofactor biosynthetic process | striatum development | olfactory lobe development | small molecule metabolic process | cellular amide metabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | pyruvate metabolic process | aromatic compound biosynthetic process | hindbrain development | phosphorylation | purine ribonucleotide biosynthetic process | carbohydrate metabolic process | nucleotide catabolic process | nucleoside triphosphate biosynthetic process | phosphate-containing compound metabolic process | olfactory bulb development | 2-oxoglutarate metabolic process | aromatic compound catabolic process | pyramidal neuron differentiation | limbic system development | drug metabolic process | carboxylic acid metabolic process | neuron differentiation | pyridine nucleotide biosynthetic process | protein metabolic process | olfactory bulb mitral cell layer development | nucleoside diphosphate metabolic process | tricarboxylic acid metabolic process | anatomical structure development | metabolic process | oxidation-reduction process | cerebellar cortex development | citrate metabolic process | forebrain generation of neurons | nucleobase-containing compound metabolic process | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | organic substance metabolic process | animal organ development | forebrain development | pallium development | ATP generation from ADP | oxoglutarate dehydrogenase (succinyl-transferring) activity | pyruvate biosynthetic process | ADP metabolic process | ribose phosphate biosynthetic process | cell development | organic acid metabolic process | cellular protein metabolic process | energy derivation by oxidation of organic compounds | developmental process | nicotinamide nucleotide metabolic process | cellular protein modification process | NAD metabolic process | carbohydrate derivative metabolic process | heterocycle metabolic process | central nervous system development | cellular metabolic process | ATP metabolic process | histone succinylation | oxidoreductase activity | oxoglutarate dehydrogenase (NAD+) activity | nucleoside diphosphate phosphorylation | nucleoside monophosphate biosynthetic process | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

mitochondrial matrix | intracellular membrane-bounded organelle | catalytic complex | organelle membrane | cell | oxidoreductase complex | cytoplasm | oxoglutarate dehydrogenase complex | intracellular organelle | protein-containing complex | transferase complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | tricarboxylic acid cycle enzyme complex | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | cytosol | intracellular | membrane