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QuickView for OPRM1 (gene)


Gene Symbol:
OPRM1 Homo sapiens Homo sapiens
Full name:
opioid receptor mu 1
Synonyms:
LMOR, M-OR-1, MOP, MOR, MOR1, OPRM, mu-type opioid receptor, mu opiate receptor, mu opioid receptor hMOR-1a
Genomic Location:
Chr 6: 154402136-154609693
Description:
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its m...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 6
6q25.2





GO Molecular Function

neurotransmitter receptor activity | peptide binding | voltage-gated ion channel activity | filamin binding | passive transmembrane transporter activity | transmembrane signaling receptor activity | neuropeptide binding | beta-endorphin receptor activity | transmembrane transporter activity | G-protein coupled receptor activity | ion gated channel activity | neuropeptide receptor activity | voltage-gated calcium channel activity | morphine receptor activity | protein domain specific binding | cytoskeletal protein binding | cation transmembrane transporter activity | amide binding | signaling receptor activity | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | opioid receptor activity | protein binding | metal ion transmembrane transporter activity | voltage-gated cation channel activity | G-protein beta-subunit binding | cation channel activity | peptide receptor activity | inorganic cation transmembrane transporter activity | G-protein coupled peptide receptor activity | voltage-gated channel activity | channel activity | calcium channel activity | melanocortin receptor activity | ion channel activity | G-protein alpha-subunit binding | protein C-terminus binding | substrate-specific channel activity

GO Biological Process

response to extracellular stimulus | adenylate cyclase-inhibiting opioid receptor signaling pathway | negative regulation of G-protein coupled receptor protein signaling pathway | regulation of ERK1 and ERK2 cascade | response to radiation | response to nutrient levels | response to cytokine | regulation of neurogenesis | response to lipopolysaccharide | negative regulation of peptide secretion | intracellular signal transduction | regulation of cell development | regulation of localization | response to isoquinoline alkaloid | establishment of localization | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | excitatory postsynaptic potential | defense response | nervous system development | response to drug | neurogenesis | positive regulation of phosphate metabolic process | negative regulation of protein secretion | voltage-gated ion channel activity | generation of neurons | response to antibiotic | cellular process | neuropeptide signaling pathway | response to morphine | localization | passive transmembrane transporter activity | negative regulation of signaling | metal ion transport | chemical synaptic transmission | multicellular organismal reproductive process | negative regulation of secretion | response to growth factor | positive regulation of nitrogen compound metabolic process | regulation of appetite | negative regulation of establishment of protein localization | regulation of neurological system process | regulation of cell differentiation | beta-endorphin receptor activity | regulation of cellular process | regulation of metabolic process | transmembrane transporter activity | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | G-protein coupled receptor activity | regulation of peptide secretion | negative regulation of lyase activity | response to stimulus | negative regulation of protein transport | ion gated channel activity | positive regulation of protein metabolic process | response to cocaine | cellular response to xenobiotic stimulus | response to stress | regulation of cell proliferation | ovulation cycle | inflammatory response to antigenic stimulus | regulation of neurotransmitter receptor activity | reproduction | divalent metal ion transport | response to alcohol | rhythmic process | response to molecule of bacterial origin | neuropeptide receptor activity | negative regulation of transport | cellular response to organic cyclic compound | regulation of protein transport | G-protein coupled receptor signaling pathway | negative regulation of Wnt protein secretion | regulation of peptide transport | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | response to ethanol | regulation of membrane potential | voltage-gated calcium channel activity | regulation of cellular response to stress | response to nitrogen compound | morphine receptor activity | response to external biotic stimulus | system development | reproductive process | regulation of signal transduction | negative regulation of secretion by cell | positive regulation of response to food | multicellular organism development | negative regulation of catalytic activity | calcium ion transmembrane transport | regulation of MAPK cascade | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of catalytic activity | regulation of phosphorylation | ion transmembrane transport | regulation of sensory perception of pain | wound healing | cellular response to ammonium ion | opioid receptor signaling pathway | regulation of postsynaptic membrane potential | response to lipid | nervous system process | regulation of response to food | synaptic signaling | cation transmembrane transporter activity | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | behavioral response to ethanol | response to ammonium ion | regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | cellular response to alkaloid | calcium ion transmembrane transporter activity | positive regulation of appetite | ion transmembrane transporter activity | positive regulation of cell differentiation | second-messenger-mediated signaling | cellular response to cytokine stimulus | locomotory behavior | sensory perception of pain | regulation of cellular protein metabolic process | eating behavior | negative regulation of adenylate cyclase activity | response to toxic substance | regulation of cyclase activity | response to xenobiotic stimulus | cellular response to drug | response to bacterium | dopamine receptor signaling pathway | cell communication | regulation of cellular metabolic process | inflammatory response | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of signal transduction | regulation of cAMP-mediated signaling | regulation of protein phosphorylation | opioid receptor activity | acute inflammatory response to antigenic stimulus | multicellular organism reproduction | cation transmembrane transport | regulation of signaling receptor activity | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | cAMP-mediated signaling | response to wounding | metal ion transmembrane transporter activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | voltage-gated cation channel activity | positive regulation of cell development | negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | cellular response to isoquinoline alkaloid | calcium ion transport | regulation of secretion | behavior | immune response | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | regulation of phosphate metabolic process | inorganic cation transmembrane transport | response to alkaloid | regulation of ion transmembrane transport | phospholipase C-activating G-protein coupled receptor signaling pathway | positive regulation of MAPK cascade | regulation of adenylate cyclase activity | cation channel activity | adult behavior | sensory perception | estrous cycle | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | transmembrane transport | signaling | feeding behavior | inorganic cation transmembrane transporter activity | G-protein coupled peptide receptor activity | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | voltage-gated channel activity | cation transport | channel activity | regulation of NMDA receptor activity | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of G-protein coupled receptor protein signaling pathway | developmental process | calcium channel activity | negative regulation of cAMP-mediated signaling | melanocortin receptor activity | regulation of transport | negative regulation of cell proliferation | regulation of cation channel activity | response to organonitrogen compound | regulation of glutamate receptor signaling pathway | ion channel activity | response to anesthetic | cellular response to morphine | positive regulation of metabolic process | ion transport | acute inflammatory response | adenylate cyclase-activating dopamine receptor signaling pathway | immune system process | cellular response to organic substance | regulation of protein localization | response to food | substrate-specific channel activity | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | dendrite | intracellular membrane-bounded organelle | sarcolemma | synapse | neuron projection | somatodendritic compartment | adherens junction | cell projection membrane | focal adhesion | cytoplasmic vesicle | cell body | cell | neuronal cell body | intrinsic component of membrane | cytoplasm | dendrite cytoplasm | cell-substrate junction | intracellular organelle | endoplasmic reticulum | membrane microdomain | dendritic tree | leading edge membrane | Golgi apparatus | cell projection | endomembrane system | postsynapse | plasma membrane bounded cell projection cytoplasm | plasma membrane | perikaryon | cell leading edge | membrane raft | vesicle | cytoplasmic region | integral component of plasma membrane | endosome | dendrite membrane | membrane-bounded organelle | organelle | cell periphery | axon | cell-substrate adherens junction | intracellular vesicle | intracellular | cell junction | membrane | neuron projection membrane | intrinsic component of plasma membrane