QuickView for ORC4 (gene)

Gene Symbol:

ORC4 Homo sapiens

Full name:

origin recognition complex subunit 4

Synonyms:

ORC4L, ORC4P, origin recognition complex subunit 4, origin recognition complex, subunit 4 homolog

Genomic Location:

Chr 2: 148408202-148495606

Description:

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ...

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The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  FOXJ2_02 ,  P53_DECAMER_Q2 ,  HFH3_01 ,  FOXO4_01 ,  YTATTTTNR_MEF2_02 ,  NGFIC_01 ,  GGGAGGRR_MAZ_Q6 ,  TCCCRNNRTGC_UNKNOWN ,  GGATTA_PITX2_Q2 ,  ALPHACP1_01 ,  ETS2_B ,  EGR_Q6 ,  TGCGCANK_UNKNOWN ,  EVI1_05 ,  HNF3B_01 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  PITX2_Q2 ,  HFH8_01 ,  TTGTTT_FOXO4_01 ,  STAT5A_04 ,  RGAGGAARY_PU1_Q6 ,  ZIC2_01 ,  EGR1_01 ,  AACTTT_UNKNOWN ,  MZF1_02 ,  YAATNANRNNNCAG_UNKNOWN ,  TGACATY_UNKNOWN ,  ETS1_B ,  FOXO4_02 ,  HNF6_Q6

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Cytogenetic Map:

2q23.1

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