QuickView for OSM (gene)

Gene Symbol:

OSM Homo sapiens

Full name:

oncostatin M

Synonyms:

oncostatin-M

Genomic Location:

Chr 22: 28988818-28992840

Description:

This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the produ...

View Full Description

This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YTCCCRNNAGGY_UNKNOWN ,  GATTGGY_NFY_Q6_01 ,  TAL1ALPHAE47_01 ,  GATA3_01 ,  IRF1_Q6 ,  GTGCAAA_MIR507 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  MYCMAX_02 ,  CEBPDELTA_Q6 ,  TAL1BETAE47_01 ,  CACCCBINDINGFACTOR_Q6 ,  GGGYGTGNY_UNKNOWN ,  STAT5B_01 ,  ATGTTAA_MIR302C ,  IRF_Q6 ,  NFY_Q6 ,  STAT_01 ,  IRF7_01 ,  SREBP_Q3 ,  GTGGGTGK_UNKNOWN ,  TTCYNRGAA_STAT5B_01 ,  STAT5A_01 ,  ISRE_01 ,  PPARA_02 ,  GTTNYYNNGGTNA_UNKNOWN ,  STTTCRNTTT_IRF_Q6 ,  SRF_C ,  IRF2_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

22q12.2

search → result