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Name: Ofloxacin
PubChem Compound ID: 11089686
Description: A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
Molecular formula: C18H20FN3O4
Molecular weight: 360.368 g/mol
Name: Ofloxacin
Name (isomeric): DB01165
Drug Type: small molecule
Description: A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.
Brand: Obide, Ofloxin, O-Flox, Bactocin, Occidal, Oflodal, Qipro, Loxinter, Quotavil, Fugacin, Tarivid, Flotavid, Mergexin, Flodemex, Tariflox, Marfloxacin, Danoflox, Liflox, Ofus, Oflox, Sinflo, Taravid, Orocin, Rilox, Floxstat, Onexacin, Pharflox, Akilen, Praxin, Uro Tarivid, Tructum, Puiritol, Flovid, Otonil, Baccidal, Exocin, Tabrin, Viotisone, Exocine, Floxil, Floxin, Oflodura, Zanocin, Oflocee, Flobacin, Operan, Qinolon, Floxal, Oflin, Novecin, Kinoxacin, Oflocin, Effexin, Kinflocin, Oflocet, Medofloxine, Nufafloqo, Oflodex, Inoflox, Quinolon, Telbit, Ofcin
Category: Anti-Bacterial Agents, Quinolones, Anti-Infective Agents, Urinary, Nucleic Acid Synthesis Inhibitors, Anti-Infectives
CAS number: 82419-36-1
Indication: For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyr...
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Mechanism of Action: Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.
Absorption: Bioavailability of ofloxacin in the tablet formulation is approximately 98%
Protein binding: 32%
Biotransformation: Hepatic
Route of elimination: Elimination is mainly by renal excretion. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. Four to eight percent of an ofloxacin dose is excreted in the feces. This indicates a small degree of biliary excretion of ofloxacin.
Half Life: 9 hours
Toxicity: LD50=5450 mg/kg (orally in mice)
Affected organisms: Enteric bacteria and other eubacteria
Food interaction:
Avoid high doses of caffeine.
Take without regard to meals.
Drug interaction:
FoscarnetIncreased risk of convulsions
AluminiumFormation of non-absorbable complexes
ProcainamideOfloxacin may increase the effect of procainamide.
WarfarinThe quinolone antibiotic, ofloxacin, may increase the anticoagulant effect of warfarin.
TizanidineOfloxacin may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
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