QuickView for Orai1 (gene)

Gene Symbol:

ORAI1 Homo sapiens

Full name:

ORAI calcium release-activated calcium modulator 1

Synonyms:

CRACM1, IMD9, ORAT1, TAM2, TMEM142A, calcium release-activated calcium channel protein 1, calcium release-activated calcium modulator 1, protein orai-1, transmembrane protein 142A

Genomic Location:

Chr 12: 120548858-120564322

Description:

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  VDR_Q3 ,  NFKAPPAB_01 ,  AP1_Q6 ,  NFKAPPAB65_01 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  AP1_Q6_01 ,  AP1FJ_Q2 ,  ATF3_Q6 ,  AP1_Q2_01 ,  SPZ1_01 ,  CREL_01 ,  AP1_Q2 ,  NFKB_Q6_01 ,  P300_01 ,  GGGNNTTTCC_NFKB_Q6_01

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Cytogenetic Map:

12q24.31

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