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QuickView for Osteocalcin (gene)


Gene Symbol:
BGLAP Homo sapiens Homo sapiens
Full name:
bone gamma-carboxyglutamate protein
Synonyms:
BGP, OC, OCN, osteocalcin, bone gamma-carboxyglutamate (gla) protein (osteocalcin), gamma-carboxyglutamic acid-containing protein
Genomic Location:
Chr 1: 154478629-154479736
Description:
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabol...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 1
1q22


Transcripts Names
NM_199173
Protein Names
P02818
Q5TCK6



GO Molecular Function

structural molecule activity | cation binding | hydroxyapatite binding | ion binding | structural constituent of bone | calcium ion binding | metal ion binding

GO Biological Process

response to extracellular stimulus | response to nutrient levels | establishment of localization | regulation of immune system process | response to hormone | response to hydroxyisoflavone | response to metal ion | bone development | cell differentiation | bone mineralization | cellular response to extracellular stimulus | response to drug | response to antibiotic | intracellular transport | regulation of bone remodeling | cellular process | localization | odontogenesis | osteoblast development | response to growth factor | regulation of myeloid cell differentiation | response to inorganic substance | establishment of localization in cell | regulation of bone mineralization | tissue development | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | regulation of cellular process | cellular response to lipid | response to gravity | response to stimulus | cellular response to vitamin | cellular localization | response to alcohol | cellular response to organic cyclic compound | response to vitamin D | response to ethanol | response to phenylpropanoid | system development | cellular response to nutrient levels | cellular response to vitamin D | multicellular organism development | response to activity | regulation of ossification | response to ketone | response to lipid | animal organ morphogenesis | response to corticosteroid | vesicle-mediated transport | response to nutrient | response to toxic substance | response to estrogen | cell communication | response to testosterone | response to zinc ion | Golgi vesicle transport | cell aging | cellular response to nutrient | response to organic substance | regulation of hemopoiesis | response to mechanical stimulus | anatomical structure development | regulation of bone resorption | regulation of tissue remodeling | cell adhesion | response to vitamin | animal organ development | regulation of cellular response to insulin stimulus | biomineral tissue development | regulation of osteoclast differentiation | ER to Golgi vesicle-mediated transport | response to organic cyclic compound | cell development | anatomical structure morphogenesis | regulation of developmental process | response to vitamin K | developmental process | ossification | osteoblast differentiation | skeletal system development | cellular response to organic substance | response to steroid hormone | aging | response to glucocorticoid | cellular response to growth factor stimulus | multicellular organismal process

GO Cellular Component

dendrite | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | intracellular organelle | endoplasmic reticulum | dendritic tree | Golgi apparatus | cell projection | endomembrane system | perikaryon | vesicle | endoplasmic reticulum lumen | extracellular region | membrane-bounded organelle | organelle | extracellular space | membrane-enclosed lumen | rough endoplasmic reticulum | intracellular | Golgi lumen