Correlation Engine 2.0
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QuickView for Osteoprotegerin (gene)

Gene Symbol:
TNFRSF11B Homo sapiens Homo sapiens
Full name:
TNF receptor superfamily member 11b
OCIF, OPG, PDB5, TR1, tumor necrosis factor receptor superfamily member 11B, osteoclastogenesis inhibitory factor, osteoprotegerin, tumor necrosis factor receptor superfamily, member 11b
Genomic Location:
Chr 8: 120004977-120033564
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the...
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8

Transcripts Names
Protein Names

GO Molecular Function

signaling receptor binding | molecular function regulator | signaling receptor activity | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity

GO Biological Process

response to extracellular stimulus | response to nutrient levels | extracellular structure organization | response to cytokine | response to metal ion | cellular response to tumor necrosis factor | negative regulation of tissue remodeling | response to drug | regulation of bone remodeling | cellular process | response to magnesium ion | response to inorganic substance | regulation of cellular process | regulation of odontogenesis of dentin-containing tooth | negative regulation of bone resorption | cellular component organization | response to stimulus | extracellular matrix organization | regulation of odontogenesis | molecular function regulator | system development | regulation of signal transduction | multicellular organism development | cytokine-mediated signaling pathway | response to nutrient | cellular response to cytokine stimulus | response to estrogen | cell communication | regulation of signaling receptor activity | receptor regulator activity | response to organic substance | regulation of animal organ morphogenesis | negative regulation of odontogenesis of dentin-containing tooth | anatomical structure development | cell surface receptor signaling pathway | regulation of bone resorption | regulation of tissue remodeling | receptor ligand activity | cytokine activity | tumor necrosis factor-mediated signaling pathway | negative regulation of odontogenesis | regulation of cell communication | response to arsenic-containing substance | signaling | regulation of developmental process | developmental process | negative regulation of bone remodeling | skeletal system development | response to tumor necrosis factor | cellular response to organic substance | signal transduction | regulation of signaling | multicellular organismal process

GO Cellular Component

extracellular matrix | cell | plasma membrane | extracellular region | extracellular space | cell periphery | membrane