QuickView for Osteoprotegerin (gene)

Gene Symbol:

TNFRSF11B Homo sapiens

Full name:

TNF receptor superfamily member 11b

Synonyms:

OCIF, OPG, PDB5, TR1, tumor necrosis factor receptor superfamily member 11B, osteoclastogenesis inhibitory factor, osteoprotegerin, tumor necrosis factor receptor superfamily, member 11b

Genomic Location:

Chr 8: 120004977-120033564

Description:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the...

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The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  AACTGGA_MIR145 ,  TGAGATT_MIR216 ,  STAT6_01 ,  STAT5A_03 ,  CAGTATT_MIR200B_MIR200C_MIR429

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-539

Cytogenetic Map:

8q24.12

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