Name: | Oxazepam |
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PubChem Compound ID: | 10880710 |
Description: | A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. |
Molecular formula: | C15H11ClN2O2 |
Molecular weight: | 287.719 g/mol |
Name: | Oxazepam |
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Name (isomeric): | DB00842 |
Drug Type: | small molecule |
Description: | A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. |
Synonyms: |
d-Oxazepam hemisuccinate; Oxozepam; Oxazipam
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Brand: | Hi-Long, Tacepam, Enidrel, Notaral, Isodin, Tazepam, Oxanid, Serenal, Ansioxacepam, Murelax, Serenid, Bonare, Uskan, Praxiten, Wy-3498 stic, Adumbran, Zaxopam, Sigacalm, QUEN, Vaben, Serpax, Drimuel, Oxa-puren, Droxacepam, Limbial, Serenid-D, Azutranquil, Astress, Durazepam, Seresta, Anxiolit, Serax, Aplakil, Sobril, Sedigoa, Rondar, Nesontil, Noctazepam, Lederpam, Psiquiwas, Serepax, Propax, Quilibrex, Pacienx |
Category: | Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives |
CAS number: | 604-75-1 |
Indication: | For the treatment of anxiety disorders and alcohol withdrawal. |
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Pharmacology: | Oxazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation. |
Mechanism of Action: |
Similar to other benzodiazepines, oxazepam exerts its anxiolytic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA-A receptors through a cooperative mechanism of action. GABA receptors are ionotropic chloride-linked channel receptors that produce inhibitory postsynaptic potentials. When activated by GABA, the GABA recepto...
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Absorption: | Well absorbed from the gastrointestinal tract following oral administration. Time to peak concentration = 2-4 hours. Onset of action is slow, > 3 hours, following oral administration. |
Protein binding: | 80-99% |
Biotransformation: | No active metabolites. Metabolized via conjugation prior to elimination. |
Route of elimination: | This product has a single, major inactive metabolite in man, a glucuronide excreted in the urine. |
Half Life: | 5-15 hours |
Toxicity: | Symptoms of overdose include confusion, drowsiness, and lethargy. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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