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QuickView for Oxazepam (compound)


PubChem
Name: Oxazepam
PubChem Compound ID: 10880710
Description: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
Molecular formula: C15H11ClN2O2
Molecular weight: 287.719 g/mol
DrugBank
Identification
Name: Oxazepam
Name (isomeric): DB00842
Drug Type: small molecule
Description: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
Synonyms:
d-Oxazepam hemisuccinate; Oxozepam; Oxazipam
Brand: Hi-Long, Tacepam, Enidrel, Notaral, Isodin, Tazepam, Oxanid, Serenal, Ansioxacepam, Murelax, Serenid, Bonare, Uskan, Praxiten, Wy-3498 stic, Adumbran, Zaxopam, Sigacalm, QUEN, Vaben, Serpax, Drimuel, Oxa-puren, Droxacepam, Limbial, Serenid-D, Azutranquil, Astress, Durazepam, Seresta, Anxiolit, Serax, Aplakil, Sobril, Sedigoa, Rondar, Nesontil, Noctazepam, Lederpam, Psiquiwas, Serepax, Propax, Quilibrex, Pacienx
Category: Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives
CAS number: 604-75-1
Pharmacology
Indication: For the treatment of anxiety disorders and alcohol withdrawal.
Pharmacology: Oxazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.
Mechanism of Action:
Similar to other benzodiazepines, oxazepam exerts its anxiolytic effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA-A receptors through a cooperative mechanism of action. GABA receptors are ionotropic chloride-linked channel receptors that produce inhibitory postsynaptic potentials. When activated by GABA, the GABA recepto...
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Absorption: Well absorbed from the gastrointestinal tract following oral administration. Time to peak concentration = 2-4 hours. Onset of action is slow, > 3 hours, following oral administration.
Protein binding: 80-99%
Biotransformation: No active metabolites. Metabolized via conjugation prior to elimination.
Route of elimination: This product has a single, major inactive metabolite in man, a glucuronide excreted in the urine.
Half Life: 5-15 hours
Toxicity: Symptoms of overdose include confusion, drowsiness, and lethargy.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol.
Avoid excessive quantities of coffee or tea (Caffeine).
Take with food.
Drug interaction:
KavaKava may increase the effect of the benzodiazepine, oxazepam.
TriprolidineThe CNS depressants, Triprolidine and Oxazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
ClozapineIncreased risk of toxicity

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