QuickView for Oxtr (gene)
- Gene Symbol:
- OXTR
Homo sapiens - Full name:
- oxytocin receptor
- Synonyms:
- OT-R, oxytocin receptor
- Genomic Location:
- Chr 3: 8767094-8786300
- Description:
-
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
3p25.3
GO Molecular Function
peptide binding | peptide hormone binding | transmembrane signaling receptor activity | oxytocin receptor activity | G-protein coupled receptor activity | amide binding | signaling receptor activity | hormone binding | peptide receptor activity | G-protein coupled peptide receptor activity | vasopressin receptor activity
GO Biological Process
brain development | regulation of blood vessel diameter | regulation of muscle system process | positive regulation of blood circulation | regulation of systemic arterial blood pressure by hormone | response to cytokine | positive regulation of cellular component organization | intracellular signal transduction | regulation of synapse assembly | regulation of localization | insemination | establishment of localization | response to hormone | positive regulation of developmental process | social behavior | nervous system development | regulation of smooth muscle contraction | response to drug | cellular chemical homeostasis | cellular process | secretion | regulation of catecholamine secretion | localization | cellular homeostasis | positive regulation of synaptic transmission | response to progesterone | response to estradiol | female pregnancy | regulation of digestive system process | multicellular organismal reproductive process | negative regulation of secretion | response to peptide hormone | oxytocin receptor activity | positive regulation of vasoconstriction | positive regulation of uterine smooth muscle contraction | regulation of cellular process | parturition | regulation of metabolic process | regulation of cytosolic calcium ion concentration | MAPK cascade | regulation of systemic arterial blood pressure mediated by a chemical signal | calcium ion homeostasis | head development | G-protein coupled receptor activity | muscle contraction | response to stimulus | maternal behavior | positive regulation of blood pressure | positive regulation of cold-induced thermogenesis | signal transduction by protein phosphorylation | regulation of blood vessel size | regulation of norepinephrine secretion | response to cocaine | response to stress | positive regulation of norepinephrine secretion | ovulation cycle | regulation of blood circulation | response to peptide | reproduction | rhythmic process | negative regulation of transport | blood circulation | G-protein coupled receptor signaling pathway | protein modification process | regulation of synapse structure or activity | modulation of chemical synaptic transmission | positive regulation of synaptic transmission, glutamatergic | macromolecule modification | metal ion homeostasis | response to nitrogen compound | cellular response to hormone stimulus | system development | response to oxygen levels | regulation of penile erection | nitrogen compound metabolic process | reproductive process | multicellular organism development | regulation of synaptic transmission, GABAergic | regulation of synaptic transmission, glutamatergic | phosphorus metabolic process | learning or memory | mammary gland development | positive regulation of catecholamine secretion | regulation of muscle contraction | telencephalon development | positive regulation of secretion | response to ketone | response to lipid | nervous system process | copulation | regulation of blood pressure | regulation of systemic arterial blood pressure | cellular ion homeostasis | sleep | response to ammonium ion | regulation of synapse organization | positive regulation of cytosolic calcium ion concentration | regulation of gastric acid secretion | cognition | regulation of uterine smooth muscle contraction | eating behavior | phosphorylation | digestive tract development | parental behavior | response to toxic substance | response to xenobiotic stimulus | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | regulation of systemic arterial blood pressure by vasopressin | cellular cation homeostasis | endocrine process | cell communication | positive regulation of smooth muscle contraction | heart development | cellular calcium ion homeostasis | homeostatic process | suckling behavior | positive regulation of synaptic transmission, GABAergic | regulation of tube size | positive regulation of synapse assembly | positive regulation of transport | sperm ejaculation | multicellular organism reproduction | maternal process involved in parturition | protein metabolic process | response to organic substance | gland development | digestive system development | lactation | anatomical structure development | response to amine | cell surface receptor signaling pathway | regulation of vasoconstriction | reproductive behavior | metabolic process | regulation of body fluid levels | positive regulation of penile erection | regulation of tube diameter | chemical homeostasis | regulation of secretion | behavior | body fluid secretion | positive regulation of muscle contraction | positive regulation of cellular component biogenesis | organic substance metabolic process | mating | animal organ development | forebrain development | ion homeostasis | response to alkaloid | negative regulation of gastric acid secretion | memory | estrous cycle | regulation of cell communication | signaling | feeding behavior | G-protein coupled peptide receptor activity | response to organic cyclic compound | cellular protein metabolic process | regulation of nervous system development | regulation of developmental process | developmental process | cellular protein modification process | tube development | regulation of transport | response to organonitrogen compound | cellular metal ion homeostasis | vasopressin receptor activity | ERK1 and ERK2 cascade | central nervous system development | response to anesthetic | response to anoxia | positive regulation of metabolic process | response to amphetamine | cellular metabolic process | cellular response to organic substance | response to steroid hormone | circulatory system development | divalent inorganic cation homeostasis | sexual reproduction | regulation of cellular component organization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
integral component of membrane | apical plasma membrane | adherens junction | actin-based cell projection | cell | intrinsic component of membrane | apical part of cell | cell-cell adherens junction | cell-cell junction | cell projection | plasma membrane | integral component of plasma membrane | microvillus | cell periphery | intracellular | cell junction | membrane | intrinsic component of plasma membrane
