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QuickView for Oxymetazoline (compound)
PubChem
| Name: | Oxymetazoline |
|---|---|
| PubChem Compound ID: | 4636 |
| Description: | A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251) |
| Molecular formula: | C16H24N2O |
| Molecular weight: | 260.375 g/mol |
| Synonyms: |
Phenol, 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-; DivK1c_000567; 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline; Oximetazolinum; 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol; SPBio_001095; Spectrum2_000998; KBioGR_000908; Tocris-1142; 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol.
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DrugBank
Identification
| Name: | Oxymetazoline |
|---|---|
| Name (isomeric): | DB00935 |
| Drug Type: | small molecule |
| Description: | A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251) |
| Synonyms: |
Oxymetozoline; Oximetazolinum; Oxymethazoline; oxymetazoline hydrochloride crystalline
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| Brand: | Genasal Nasal Spray Up to 12 Hour Relief, Afrin Original 12 Hour Nose Drops, Duramist Plus Up To 12 Hour Nasal Decongestant Spray, Afrin, Nasivine, Nostrilla 12 Hour Nasal Decongestant, Vicks Sinex 12 Hour Nasal Spray, Rhinolitan, Oxylazine, Nafrine, Rhinofrenol, Afrin Extra Moisturizing 12 Hour Nasal Spray, Sinerol, Dristan Long Lasting Mentholated Nasal Spray, Iliadin, Visine L.R, Duration 12 Hour Nasal Spray, Navisin, Afrin Original 12 Hour Pump Mist, Drixoral Nasal Solution, OcuClear, Afrin Sinus 12 Hour Nasal Spray, Hazol, Afrin Cherry 12 Hour Nasal Spray, Neo-Synephrine 12 Hour Spray, Navasin, Visine L.R., Nasal Relief 12 Hour Nasal Spray, Afrin Original 12 Hour Nasal Spray, Vicks Sinex 12 Hour Ultra Fine Mist for Sinus Relief, Dristan Long Lasting Nasal Mist, Nezeril |
| Category: | Adrenergic alpha-Agonists, Sympathomimetics, Nasal Decongestants |
| CAS number: | 1491-59-4 |
Pharmacology
| Indication: | For treatment of nasal congestion and redness associated with minor irritations of the eye |
|---|---|
| Pharmacology: |
Oxymetazoline a adrenergic alpha-agonists, direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion The sympathomimetic action of oxymetazoline constricts the smaller arterioles of the nasal passages, producing a prolonged (up to 12 hours), gentle and decongesting effect. Oxymetazoline elicits relief of conjunctival hyper...
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| Mechanism of Action: | Oxymetazoline is a direct acting sympathomimetic amine, which acts on alpha-adrenergic receptors in the arterioles of the conjunctiva and nasal mucosa. It produces vasoconstriction, resulting in decreased conjunctival congestion in ophthalmic. In nasal it produces constriction, resulting in decreased blood flow and decreased nasal congestion. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
