Name: | P-Glycoprotein |
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Description: | A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE). |
Synonyms: |
P-gp; Multidrug Resistance Protein 1; PGY 1 Protein; PGY-1 Protein; P Glycoprotein; MDR1 Protein; ATP-Binding Cassette, Sub-Family B, Member 1
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