QuickView for P2RX7;jsessionid=58322502BA86313AB0CEA76B6EB3C362 (gene)
- Gene Symbol:
- P2RX7
Homo sapiens - Full name:
- purinergic receptor P2X 7
- Synonyms:
- P2X7, P2X purinoceptor 7, ATP receptor, P2X7 receptor, P2Z receptor, purinergic receptor P2X, ligand gated ion channel, 7, purinergic receptor P2X7 variant A
- Genomic Location:
- Chr 12: 120055061-120108259
- Description:
-
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellula...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Canis lupus familiaris , Pan troglodytes , Gallus gallus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
12q24.31
GO Molecular Function
ATP-gated ion channel activity | passive transmembrane transporter activity | transmembrane signaling receptor activity | ribonucleotide binding | transmembrane transporter activity | lipid binding | ligand-gated ion channel activity | nucleotide binding | ion gated channel activity | signaling receptor binding | carbohydrate derivative binding | ATP binding | anion binding | adenyl nucleotide binding | cation transmembrane transporter activity | signaling receptor activity | purine nucleotide binding | transporter activity | identical protein binding | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | lipopolysaccharide binding | excitatory extracellular ligand-gated ion channel activity | cation channel activity | inorganic cation transmembrane transporter activity | purine ribonucleotide binding | adenyl ribonucleotide binding | channel activity | drug binding | purinergic nucleotide receptor activity | ion channel activity | heterocyclic compound binding | extracellularly ATP-gated cation channel activity | substrate-specific channel activity | small molecule binding
GO Biological Process
positive regulation of immune response | synaptic vesicle exocytosis | leukocyte homeostasis | positive regulation of cell killing | response to extracellular stimulus | regulation of T cell mediated immunity | negative regulation of phosphorylation | membrane protein proteolysis | regulation of interleukin-1 beta production | cell morphogenesis | NAD transport | response to nutrient levels | negative regulation of MAPK cascade | response to ATP | exocytosis | positive regulation of cellular component organization | neurotransmitter secretion | response to lipopolysaccharide | regulation of cellular localization | positive regulation of ATP metabolic process | intracellular signal transduction | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | proteolysis | homeostasis of number of cells within a tissue | cytosolic calcium ion transport | regulation of localization | regulation of carbohydrate metabolic process | lipid transport | regulation of programmed cell death | regulation of sodium ion transport | defense response to other organism | establishment of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | protein processing | response to metal ion | negative regulation of tissue remodeling | excitatory postsynaptic potential | purinergic nucleotide receptor signaling pathway | regulation of T cell mediated cytotoxicity | ATP-gated ion channel activity | defense response | cellular response to extracellular stimulus | response to drug | reactive oxygen species metabolic process | negative regulation of protein phosphorylation | cellular chemical homeostasis | positive regulation of biomineral tissue development | regulation of leukocyte mediated cytotoxicity | positive regulation of interleukin-1 beta secretion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of protein secretion | membrane organization | tissue homeostasis | intracellular transport | regulation of lipid transport | regulation of bone remodeling | response to organophosphorus | positive regulation of cellular biosynthetic process | cellular process | secretion | organic substance catabolic process | establishment of organelle localization | localization | cellular homeostasis | regulation of gamma-aminobutyric acid secretion | regulation of glycolytic process | extrinsic apoptotic signaling pathway | passive transmembrane transporter activity | regulation of mitochondrial membrane potential | negative regulation of signaling | metal ion transport | positive regulation of immune effector process | chemical synaptic transmission | positive regulation of adaptive immune response | anion transport | positive regulation of protein kinase activity | macromolecule localization | hemostasis | endomembrane system organization | sphingolipid metabolic process | negative regulation of cell volume | positive regulation of catalytic activity | regulation of cytolysis | positive regulation of nitrogen compound metabolic process | response to inorganic substance | regulation of membrane lipid distribution | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of bone mineralization | anatomical structure homeostasis | regulation of lymphocyte apoptotic process | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | catabolic process | regulation of cytosolic calcium ion concentration | organelle localization | transmembrane transporter activity | phospholipid transfer to membrane | positive regulation of cellular protein metabolic process | ligand-gated ion channel activity | cellular response to organonitrogen compound | regulation of mitochondrial depolarization | negative regulation of bone resorption | cellular component organization | cellular lipid metabolic process | calcium ion homeostasis | T cell activation | calcium ion transport into cytosol | regulation of peptide secretion | response to stimulus | positive regulation of interleukin-1 beta production | ion gated channel activity | positive regulation of mitochondrial depolarization | positive regulation of immune system process | positive regulation of protein metabolic process | mononuclear cell proliferation | response to stress | membrane protein ectodomain proteolysis | cellular nitrogen compound biosynthetic process | ceramide metabolic process | multicellular organismal homeostasis | calcium-mediated signaling using extracellular calcium source | programmed cell death | sphingolipid biosynthetic process | cellular localization | divalent metal ion transport | secretion by cell | positive regulation of cytokine secretion | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | response to ischemia | cellular response to organic cyclic compound | regulation of protein transport | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | cellular component assembly | protein modification process | regulation of peptide transport | cellular biosynthetic process | mitochondrion organization | macromolecule modification | cell-cell signaling | activation of protein kinase activity | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | blood coagulation | positive regulation of peptide secretion | regulation of membrane potential | regulation of neurotransmitter levels | response to nitrogen compound | apoptotic process | organelle assembly | regulation of calcium ion transport into cytosol | synaptic vesicle cycle | regulation of cell projection assembly | response to external biotic stimulus | system development | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of phosphate metabolic process | positive regulation of icosanoid secretion | multicellular organism development | calcium ion transmembrane transport | regulation of MAPK cascade | phosphorus metabolic process | response to purine-containing compound | response to dsRNA | positive regulation of glutamate secretion | protein complex oligomerization | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of killing of cells of other organism | regulation of phosphorylation | ion transmembrane transport | regulation of ossification | plasma membrane organization | wound healing | positive regulation of interleukin-1 alpha production | regulation of gene expression | regulation of postsynaptic membrane potential | cellular response to ATP | positive regulation of secretion | organic substance transport | response to lipid | nervous system process | protein catabolic process | synaptic signaling | cation transmembrane transporter activity | cell projection assembly | regulation of membrane depolarization | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | animal organ morphogenesis | positive regulation of ion transmembrane transport | positive regulation of ATP biosynthetic process | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | phagosome maturation | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | cellular amide metabolic process | vesicle-mediated transport | response to nutrient | ion transmembrane transporter activity | second-messenger-mediated signaling | homeostasis of number of cells | positive regulation of glycolytic process | establishment of vesicle localization | cell proliferation | leukocyte proliferation | biosynthetic process | negative regulation of sequestering of calcium ion | sensory perception of pain | regulation of cellular protein metabolic process | extracellular ligand-gated ion channel activity | positive regulation of ossification | organic anion transport | phosphorylation | regulated exocytosis | positive regulation of interleukin-1 secretion | lipid biosynthetic process | positive regulation of cytolysis | protein maturation | regulation of glutamate secretion | positive regulation of leukocyte apoptotic process | positive regulation of lipid localization | pore complex assembly | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | vacuole organization | cellular response to drug | response to bacterium | positive regulation of bleb assembly | regulation of interleukin-1 production | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | lysosome organization | positive regulation of interleukin-1 production | skeletal system morphogenesis | lymphocyte homeostasis | inflammatory response | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | cellular response to dsRNA | defense response to bacterium | homeostatic process | positive regulation of establishment of protein localization | response to zinc ion | regulation of protein phosphorylation | positive regulation of transport | coagulation | apoptotic signaling pathway | lymphocyte activation | positive regulation of molecular function | release of sequestered calcium ion into cytosol | calcium-mediated signaling | regulation of cytokine secretion | activation of MAPK activity | cation transmembrane transport | phospholipid transport | protein-containing complex assembly | protein metabolic process | cellular response to nutrient | regulation of establishment of protein localization | positive regulation of interleukin-1 alpha secretion | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | response to wounding | response to mechanical stimulus | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | nucleobase-containing compound transport | cofactor transport | cell surface receptor signaling pathway | cell projection organization | metabolic process | lipid localization | membrane lipid metabolic process | regulation of interleukin-1 beta secretion | regulation of adaptive immune response | regulation of body fluid levels | regulation of bone resorption | regulation of tissue remodeling | calcium ion regulated exocytosis | chemical homeostasis | calcium ion transport | endocytosis | regulation of secretion | positive regulation of cell death | membrane depolarization | positive regulation of interleukin-6 production | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of sequestering of calcium ion | phospholipid scrambling | cell death | positive regulation of T cell mediated cytotoxicity | positive regulation of amino acid transport | animal organ development | positive regulation of ion transport | excitatory extracellular ligand-gated ion channel activity | negative regulation of cellular protein metabolic process | T cell proliferation | gene expression | amide biosynthetic process | regulation of protein secretion | positive regulation of programmed cell death | positive regulation of kinase activity | ion homeostasis | regulation of ATP metabolic process | regulation of phosphate metabolic process | inorganic cation transmembrane transport | regulation of ion transmembrane transport | positive regulation of organic acid transport | T cell homeostasis | positive regulation of gamma-aminobutyric acid secretion | vesicle organization | positive regulation of cytokine production | vesicle budding from membrane | cell activation | positive regulation of MAPK cascade | positive regulation of T cell mediated immunity | positive regulation of lymphocyte apoptotic process | positive regulation of protein transport | cation channel activity | negative regulation of protein metabolic process | sensory perception | positive regulation of carbohydrate metabolic process | organonitrogen compound catabolic process | lymphocyte proliferation | defense response to Gram-positive bacterium | response to fluid shear stress | regulation of cell communication | negative regulation of signal transduction | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | response to organic cyclic compound | synaptic vesicle localization | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | regulation of cytokine production | anatomical structure morphogenesis | cation transport | channel activity | positive regulation of MAP kinase activity | positive regulation of plasma membrane bounded cell projection assembly | positive regulation of calcium ion transport into cytosol | collagen metabolic process | response to biotic stimulus | bleb assembly | regulation of developmental process | regulation of ion transport | developmental process | organelle organization | positive regulation of anion transport | purinergic nucleotide receptor activity | regulation of calcium ion transport | phospholipid translocation | cellular protein modification process | positive regulation of prostaglandin secretion | phagolysosome assembly | regulation of transport | positive regulation of leukocyte mediated cytotoxicity | neurotransmitter transport | regulation of fatty acid transport | signal release | response to organonitrogen compound | cytolysis | cellular metal ion homeostasis | response to electrical stimulus | regulation of anion transport | response to calcium ion | negative regulation of bone remodeling | ion channel activity | regulation of generation of precursor metabolites and energy | positive regulation of metabolic process | vesicle localization | ion transport | regulation of cell projection organization | skeletal system development | positive regulation of lipid transport | immune system process | cellular metabolic process | synaptic vesicle transport | cellular response to organic substance | regulation of protein localization | regulation of cell death | ceramide biosynthetic process | extracellularly ATP-gated cation channel activity | regulation of interleukin-6 production | divalent inorganic cation homeostasis | substrate-specific channel activity | phagocytosis | regulation of cellular component organization | positive regulation of calcium ion transport | positive regulation of bone mineralization | cell volume homeostasis | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of fatty acid transport | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
bleb | integral component of organelle membrane | integral component of membrane | organelle inner membrane | intracellular membrane-bounded organelle | synapse | somatodendritic compartment | organelle membrane | neuromuscular junction | nuclear membrane | cell body | cell | neuronal cell body | nuclear inner membrane | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | presynapse | cell-cell junction | cell projection | endomembrane system | postsynapse | plasma membrane | nuclear envelope | integral component of plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | integral component of nuclear inner membrane | cell surface | intracellular | cell junction | membrane | intrinsic component of plasma membrane
