QuickView for P38beta (gene)
- Gene Symbol:
- MAPK11
Homo sapiens - Full name:
- mitogen-activated protein kinase 11
- Synonyms:
- P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, mitogen-activated protein kinase 11, MAP kinase 11, MAP kinase p38 beta, mitogen-activated protein kinase p38 beta, mitogen-activated protein kinase p38-2, stress-activated protein kinase-2, stress-activated protein kinase-2b
- Genomic Location:
- Chr 22: 49044269-49050906
- Description:
-
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses throu...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
22q13.33
GO Molecular Function
ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | MAP kinase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | positive regulation of erythrocyte differentiation | response to virus | response to cytokine | response to interleukin-1 | intracellular signal transduction | regulation of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | regulation of heart growth | negative regulation of organ growth | positive regulation of phosphate metabolic process | positive regulation of protein secretion | regulation of cardiac muscle cell proliferation | cellular process | negative regulation of muscle organ development | negative regulation of developmental growth | regulation of striated muscle tissue development | positive regulation of protein kinase activity | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | positive regulation of muscle cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | MAPK cascade | negative regulation of cardiac muscle tissue development | regulation of peptide secretion | response to stimulus | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | protein serine/threonine kinase activity | positive regulation of cytokine secretion | cellular nitrogen compound metabolic process | negative regulation of muscle tissue development | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | protein modification process | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of growth | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of gene expression | positive regulation of secretion | cellular response to stress | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of interleukin-12 secretion | regulation of nitrogen compound metabolic process | positive regulation of interleukin-12 production | positive regulation of intracellular signal transduction | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | cellular response to cytokine stimulus | biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | MAP kinase activity | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of cardiac muscle cell proliferation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of striated muscle tissue development | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | cellular response to virus | positive regulation of molecular function | regulation of cytokine secretion | activation of MAPK activity | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of cardiac muscle tissue development | regulation of hemopoiesis | regulation of kinase activity | regulation of intracellular signal transduction | metabolic process | regulation of RNA biosynthetic process | regulation of erythrocyte differentiation | regulation of secretion | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | gene expression | regulation of protein secretion | positive regulation of kinase activity | regulation of phosphate metabolic process | transcription, DNA-templated | positive regulation of cytokine production | positive regulation of MAPK cascade | positive regulation of protein transport | regulation of cell communication | signaling | regulation of transcription, DNA-templated | regulation of developmental growth | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | regulation of organ growth | response to biotic stimulus | regulation of developmental process | kinase activity | regulation of muscle cell differentiation | cellular response to interleukin-1 | cellular protein modification process | regulation of transport | negative regulation of cell proliferation | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | positive regulation of interleukin-12 secretion | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
