QuickView for P4HA1 (gene)
- Gene Symbol:
- P4HA1
Homo sapiens - Full name:
- prolyl 4-hydroxylase subunit alpha 1
- Synonyms:
- P4HA, prolyl 4-hydroxylase subunit alpha-1, C-P4Halpha(I), collagen prolyl 4-hydroxylase alpha(I), procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I, procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1, prolyl 4-hydroxylase, alpha polypeptide I
- Genomic Location:
- Chr 10: 74436981-74526630
- Description:
-
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxyla...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
10q22.1
GO Molecular Function
cofactor binding | cation binding | L-ascorbic acid binding | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | carboxylic acid binding | procollagen-proline 4-dioxygenase activity | vitamin binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | iron ion binding | coenzyme binding | peptidyl-proline dioxygenase activity | monosaccharide binding | catalytic activity | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | anion binding | peptidyl-proline 4-dioxygenase activity | identical protein binding | ion binding | carbohydrate binding | protein binding | dioxygenase activity | transition metal ion binding | organic acid binding | metal ion binding | oxidoreductase activity | small molecule binding
GO Biological Process
extracellular structure organization | peptidyl-amino acid modification | cellular process | peptidyl-proline modification | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | cellular amino acid metabolic process | procollagen-proline 4-dioxygenase activity | cellular component organization | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors | supramolecular fiber organization | extracellular matrix organization | peptidyl-proline hydroxylation | peptidyl-proline dioxygenase activity | protein modification process | macromolecule modification | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | nitrogen compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 4-hydroxyproline metabolic process | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | peptidyl-proline 4-dioxygenase activity | small molecule metabolic process | protein hydroxylation | carboxylic acid metabolic process | protein metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | dioxygenase activity | collagen fibril organization | organic acid metabolic process | cellular protein metabolic process | cellular protein modification process | cellular modified amino acid metabolic process | cellular metabolic process | oxidoreductase activity | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | oxidoreductase complex | cytoplasm | intracellular organelle | endoplasmic reticulum | protein-containing complex | endomembrane system | procollagen-proline 4-dioxygenase complex | endoplasmic reticulum lumen | mitochondrion | membrane-bounded organelle | organelle | membrane-enclosed lumen | intracellular | membrane
