Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for P75NTR (gene)


Gene Symbol:
NGFR Homo sapiens Homo sapiens
Full name:
nerve growth factor receptor
Synonyms:
CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, tumor necrosis factor receptor superfamily member 16, NGF receptor, TNFR superfamily, member 16, low affinity neurotrophin receptor p75NTR, low-affinity nerve growth factor receptor, p75 ICD
Genomic Location:
Chr 17: 44927666-44947360
Description:
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q21.33


Transcripts Names
NM_002507
Protein Names
B2R961
P08138



GO Molecular Function

nerve growth factor binding | neurotrophin binding | GTPase binding | coreceptor activity | transmembrane signaling receptor activity | enzyme binding | Ras GTPase binding | growth factor binding | ubiquitin-like protein ligase binding | death receptor activity | signaling receptor activity | protein binding | ubiquitin protein ligase binding | small GTPase binding | Rab GTPase binding | calmodulin binding

GO Biological Process

membrane protein proteolysis | cell morphogenesis | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to cytokine | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | regulation of cell development | regulation of localization | regulation of programmed cell death | negative regulation of cysteine-type endopeptidase activity | establishment of localization | neuron death | negative regulation of cellular process | positive regulation of developmental process | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | cellular response to tumor necrosis factor | cell differentiation | nervous system development | regulation of sprouting angiogenesis | cell part morphogenesis | positive regulation of axonogenesis | neurogenesis | glucose homeostasis | positive regulation of phosphate metabolic process | generation of neurons | intracellular transport | negative regulation of proteolysis | positive regulation of cellular biosynthetic process | cellular process | negative regulation of axonogenesis | regulation of glucose import | circadian regulation of gene expression | localization | cell projection morphogenesis | protein transport | neuron development | macromolecule localization | negative regulation of apoptotic process | axon guidance | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular component organization | negative regulation of cell morphogenesis involved in differentiation | regulation of vasculature development | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | positive regulation of protein metabolic process | positive regulation of peptidase activity | neuron projection guidance | intracellular protein transport | positive regulation of cellular protein localization | regulation of cell proliferation | negative regulation of neuron projection development | negative regulation of angiogenesis | response to peptide | positive regulation of cysteine-type endopeptidase activity | circadian rhythm | programmed cell death | cellular localization | rhythmic process | positive regulation of proteolysis | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of nucleic acid-templated transcription | locomotion | response to nitrogen compound | apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of neuron projection development | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | regulation of axonogenesis | regulation of catalytic activity | regulation of phosphorylation | negative regulation of peptidase activity | regulation of neuron differentiation | regulation of gene expression | axon development | organic substance transport | cellular response to peptide | death receptor activity | regulation of glucose import in response to insulin stimulus | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of pri-miRNA transcription by RNA polymerase II | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | neuron apoptotic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | positive regulation of cell projection organization | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | axonogenesis | positive regulation of hydrolase activity | positive regulation of cell differentiation | cellular response to cytokine stimulus | membrane protein intracellular domain proteolysis | positive regulation of protein localization to nucleus | regulation of cellular protein metabolic process | neurotrophin signaling pathway | positive regulation of pri-miRNA transcription by RNA polymerase II | positive regulation of endopeptidase activity | cell morphogenesis involved in differentiation | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | cell communication | regulation of cellular metabolic process | cellular response to amyloid-beta | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | regulation of protein phosphorylation | regulation of RNA metabolic process | negative regulation of sprouting angiogenesis | positive regulation of molecular function | neuron differentiation | regulation of cell morphogenesis involved in differentiation | negative regulation of epithelial cell proliferation | protein metabolic process | positive regulation of protein modification process | response to organic substance | negative regulation of cell projection organization | neurotrophin TRK receptor signaling pathway | Rho protein signal transduction | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | cellular protein localization | amide transport | negative regulation of endothelial cell proliferation | chemical homeostasis | positive regulation of cell death | neuron projection development | organic substance metabolic process | cell death | regulation of glucose transmembrane transport | regulation of endothelial cell proliferation | negative regulation of neuron differentiation | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | tumor necrosis factor-mediated signaling pathway | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | establishment of protein localization | positive regulation of MAPK cascade | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | signaling | response to amyloid-beta | regulation of transcription, DNA-templated | cell development | protein localization | regulation of epithelial cell proliferation | positive regulation of phosphorylation | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule localization | regulation of nervous system development | regulation of developmental process | developmental process | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | negative regulation of vasculature development | Ras protein signal transduction | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | negative regulation of hydrolase activity | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | response to tumor necrosis factor | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | negative regulation of cell development | carbohydrate homeostasis | chemotaxis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | endomembrane system | nucleoplasm | plasma membrane | vesicle | integral component of plasma membrane | endosome | extracellular region | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular vesicle | cell surface | intracellular | membrane | intrinsic component of plasma membrane