QuickView for PABPC1;jsessionid=025EF5FECEE11645C1A2480A8FD1E277 (gene)

Gene Symbol:

PABPC1 Homo sapiens

Full name:

poly(A) binding protein cytoplasmic 1

Synonyms:

PAB1, PABP, PABP1, PABPC2, PABPL1, polyadenylate-binding protein 1, poly(A) binding protein, cytoplasmic 2

Genomic Location:

Chr 8: 101784320-101803491

Description:

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first s...

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This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Schizosaccharomyces pombe ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YTCCCRNNAGGY_UNKNOWN ,  CMYB_01 ,  PU1_Q6 ,  HNF1_01 ,  HEN1_01 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  GCAAGGA_MIR502 ,  NGFIC_01 ,  MAX_01 ,  GGGACCA_MIR133A_MIR133B ,  ATF4_Q2 ,  VDR_Q6 ,  AP2GAMMA_01 ,  AP2ALPHA_01 ,  MYCMAX_B ,  CREB_Q4 ,  GGGAGGRR_MAZ_Q6 ,  PAX4_02 ,  TGCGCANK_UNKNOWN ,  AP2_Q6_01 ,  SP3_Q3 ,  ATTCTTT_MIR186 ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  USF_C ,  HIF1_Q5 ,  ACTAYRNNNCCCR_UNKNOWN ,  SPZ1_01 ,  AP2_Q3 ,  AHRARNT_01 ,  ACCGAGC_MIR423 ,  MYB_Q6 ,  NMYC_01 ,  AP2_Q6 ,  SCGGAAGY_ELK1_02 ,  CREB_Q2 ,  RGAGGAARY_PU1_Q6 ,  RCGCANGCGY_NRF1_Q6 ,  FOXM1_01 ,  AACTTT_UNKNOWN ,  USF_02 ,  ETS1_B ,  HIF1_Q3 ,  ELF1_Q6 ,  NFKB_Q6 ,  CEBPGAMMA_Q6 ,  PAX4_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-423 ,  Predicted Gene Targets for miR-452

Cytogenetic Map:

8q22.3

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