QuickView for PAWR;jsessionid=5DEFB28AA6506D852E208E7810A68700 (gene)

Gene Symbol:

PAWR Homo sapiens

Full name:

pro-apoptotic WT1 regulator

Synonyms:

PAR4, Par-4, PRKC apoptosis WT1 regulator protein, PRKC, apoptosis, WT1, regulator, WT1-interacting protein, prostate apoptosis response protein 4, prostate apoptosis response protein PAR-4, prostate apoptosis response-4, transcriptional repressor PAR4

Genomic Location:

Chr 12: 78509876-78608921

Description:

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of th...

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This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TACTTGA_MIR26A_MIR26B ,  TTGTTT_FOXO4_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-30

Cytogenetic Map:

12q21.2

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