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QuickView for PAX2 (gene)


Gene Symbol:
PAX2 Homo sapiens Homo sapiens
Full name:
paired box 2
Synonyms:
FSGS7, PAPRS, paired box protein Pax-2, paired box homeotic gene 2
Genomic Location:
Chr 10: 102495458-102579688
Description:
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to re...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Danio rerio Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
PR_Q2 IRF1_01 NFMUE1_Q6 CGGAARNGGCNG_UNKNOWN PU1_Q6 CTCTATG_MIR368 TCANNTGAY_SREBP1_01 OCT1_04 HEN1_01 GATA_Q6
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 10
10q24.31





GO Molecular Function

sequence-specific DNA binding | oxidoreductase activity, acting on NAD(P)H | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | superoxide-generating NADPH oxidase activity | proximal promoter sequence-specific DNA binding | nucleic acid binding | catalytic activity | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | pronephros development | response to extracellular stimulus | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | brain development | regulation of epithelial cell differentiation involved in kidney development | cell morphogenesis | inner ear morphogenesis | nephron tubule formation | positive regulation of macromolecule biosynthetic process | oxidoreductase activity, acting on NAD(P)H | regulation of cysteine-type endopeptidase activity | response to nutrient levels | cellular response to glucose stimulus | neuron projection morphogenesis | intracellular signal transduction | morphogenesis of an epithelium | kidney rudiment formation | regulation of programmed cell death | metanephric nephron tubule formation | eye development | negative regulation of cysteine-type endopeptidase activity | mesodermal cell fate specification | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | embryonic camera-type eye morphogenesis | negative regulation of RNA biosynthetic process | cell differentiation | positive regulation of epithelial cell proliferation | nervous system development | response to drug | reactive oxygen species metabolic process | cellular chemical homeostasis | cell part morphogenesis | negative regulation of apoptotic process involved in morphogenesis | neurogenesis | glucose homeostasis | generation of neurons | response to antibiotic | mesenchyme development | negative regulation of proteolysis | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | positive regulation of glomerulus development | cellular homeostasis | cell projection morphogenesis | epithelial tube morphogenesis | mesoderm morphogenesis | neuron development | mesoderm development | metanephric epithelium development | optic cup morphogenesis involved in camera-type eye development | superoxide-generating NADPH oxidase activity | negative regulation of nucleic acid-templated transcription | renal tubule morphogenesis | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | regulation of proteolysis | response to growth factor | regulation of cytolysis | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | metanephric nephron development | cellular response to retinoic acid | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | metanephric nephron morphogenesis | regulation of nephron tubule epithelial cell differentiation | cranial nerve morphogenesis | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | urogenital system development | anatomical structure arrangement | nephron tubule morphogenesis | head development | cranial nerve development | negative regulation of mesenchymal cell apoptotic process involved in metanephros development | response to stimulus | cell morphogenesis involved in neuron differentiation | nephric duct morphogenesis | collecting duct development | embryonic epithelial tube formation | vestibulocochlear nerve formation | metanephric distal convoluted tubule development | optic nerve structural organization | mesoderm formation | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | response to glucose | regulation of epithelial cell differentiation | epithelial tube formation | cellular nitrogen compound metabolic process | cellular response to toxic substance | regulation of stem cell population maintenance | negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis | metanephros morphogenesis | brain morphogenesis | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | kidney development | embryo development | regulation of morphogenesis of a branching structure | regulation of metanephros size | negative regulation of apoptotic process involved in development | regulation of nucleic acid-templated transcription | protein kinase B signaling | system development | nitrogen compound metabolic process | ureteric bud development | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | cellular glucose homeostasis | regulation of peptidase activity | regulation of catalytic activity | cellular response to oxidative stress | kidney morphogenesis | regulation of metanephric nephron tubule epithelial cell differentiation | negative regulation of peptidase activity | regulation of gene expression | kidney epithelium development | axon development | neural tube closure | mesenchymal cell differentiation involved in kidney development | cellular response to stress | response to lipid | nervous system process | positive regulation of metanephric DCT cell differentiation | optic nerve development | positive regulation of cellular metabolic process | animal organ morphogenesis | specification of animal organ identity | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | neural tube formation | regulation of transcription by RNA polymerase II | response to oxidative stress | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | axonogenesis | positive regulation of cell differentiation | stem cell differentiation | negative regulation of cytolysis | renal vesicle morphogenesis | embryonic camera-type eye development | biosynthetic process | neural tube development | ureter maturation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | cell differentiation involved in kidney development | glial cell differentiation | mesonephric epithelium development | nephric duct formation | mesenchymal to epithelial transition involved in metanephros morphogenesis | response to toxic substance | cell morphogenesis involved in differentiation | mesonephros development | mesenchymal to epithelial transition | sensory organ development | mesodermal cell fate commitment | cellular response to drug | chordate embryonic development | animal organ formation | cell communication | metanephric mesenchymal cell differentiation | regulation of cellular metabolic process | eye morphogenesis | metanephros development | renal tubule development | cell differentiation involved in metanephros development | nephric duct development | regulation of protein metabolic process | inner ear development | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | pronephric field specification | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | cochlea morphogenesis | renal system development | response to retinoic acid | embryonic morphogenesis | metanephric nephron tubule morphogenesis | negative regulation of apoptotic process involved in metanephric nephron tubule development | nephron development | cellular response to epidermal growth factor stimulus | neuron differentiation | embryonic organ morphogenesis | ureteric bud morphogenesis | DNA-binding transcription factor activity | negative regulation of stem cell population maintenance | regionalization | optic chiasma development | response to organic substance | tissue morphogenesis | branching morphogenesis of an epithelial tube | retina development in camera-type eye | regulation of animal organ morphogenesis | positive regulation of metanephric glomerulus development | anatomical structure development | metanephric renal vesicle morphogenesis | cell projection organization | metabolic process | metanephric collecting duct development | cell fate commitment | mesenchymal cell differentiation | visual perception | positive regulation of branching involved in ureteric bud morphogenesis | regulation of RNA biosynthetic process | developmental maturation | oxidation-reduction process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | positive regulation of optic nerve formation | ear development | cellular response to carbohydrate stimulus | cellular response to hydrogen peroxide | chemical homeostasis | morphogenesis of embryonic epithelium | nucleobase-containing compound metabolic process | negative regulation of mesenchymal cell apoptotic process | optic nerve morphogenesis | cellular response to reactive oxygen species | neuron projection development | embryonic camera-type eye formation | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | nephron morphogenesis | animal organ development | response to reactive oxygen species | positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis | nerve development | sensory perception of light stimulus | negative regulation of cellular protein metabolic process | gene expression | metanephric tubule development | vestibulocochlear nerve development | regulation of kidney size | transcription, DNA-templated | response to epidermal growth factor | morphogenesis of a branching epithelium | camera-type eye development | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | sensory perception | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis | cell development | regulation of epithelial cell proliferation | distal tubule development | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | cell fate commitment involved in formation of primary germ layer | camera-type eye morphogenesis | regulation of nervous system development | regulation of developmental process | renal vesicle development | metanephric tubule morphogenesis | developmental process | metanephric tubule formation | ureter development | metanephric distal tubule development | positive regulation of epithelial cell differentiation | tube development | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | metanephric mesenchyme development | positive regulation of kidney development | positive regulation of nucleic acid-templated transcription | cell fate determination | cochlea development | tube closure | epithelial cell differentiation | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of apoptotic process involved in development | negative regulation of hydrolase activity | tube formation | regulation of branching involved in ureteric bud morphogenesis | central nervous system development | mesodermal cell differentiation | positive regulation of metabolic process | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | gastrulation | cellular metabolic process | embryonic eye morphogenesis | cellular response to organic substance | regulation of cell death | response to carbohydrate | oxidoreductase activity | retinal pigment epithelium development | negative regulation of cell death | metanephric nephron tubule development | aging | carbohydrate homeostasis | ear morphogenesis | mesenchymal cell differentiation involved in renal system development | nephron tubule development | negative regulation of apoptotic process involved in metanephric collecting duct development | negative regulation of reactive oxygen species metabolic process | signal transduction | negative regulation of endopeptidase activity | mesonephric tubule development | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | microtubule organizing center | cell | nuclear lumen | nucleolus | cytoplasm | centriolar satellite | intracellular organelle | centrosome | Golgi apparatus | protein-containing complex | endomembrane system | protein-DNA complex | vacuole | microtubule cytoskeleton | lytic vacuole | membrane-bounded organelle | nucleus | organelle | lysosome | membrane-enclosed lumen | cytoskeleton | intracellular