Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward Export SNPs

QuickView for PBX1 (gene)


Gene Symbol:
PBX1 Homo sapiens Homo sapiens
Full name:
PBX homeobox 1
Synonyms:
CAKUHED, pre-B-cell leukemia transcription factor 1, homeobox protein PBX1, homeobox protein PRL, pre-B-cell leukemia homeobox 1
Genomic Location:
Chr 1: 162795561-163082934
Description:
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-ce...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1
1q23.3





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | limb development | Notch signaling pathway | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | regulation of neurogenesis | developmental process involved in reproduction | regulation of cell development | morphogenesis of an epithelium | somatic stem cell population maintenance | positive regulation of G2/M transition of mitotic cell cycle | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | embryonic appendage morphogenesis | cell differentiation | nervous system development | neurogenesis | generation of neurons | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | epithelial tube morphogenesis | limb morphogenesis | immune system development | renal tubule morphogenesis | stem cell population maintenance | branching involved in ureteric bud morphogenesis | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | tissue development | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | steroid biosynthetic process | regulation of G2/M transition of mitotic cell cycle | urogenital system development | nephron tubule morphogenesis | response to stimulus | thymus development | embryonic limb morphogenesis | regulation of mitotic cell cycle phase transition | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | regulation of cell cycle phase transition | reproduction | embryonic skeletal system development | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of RNA biosynthetic process | hemopoiesis | cellular biosynthetic process | kidney development | embryo development | positive regulation of transcription of Notch receptor target | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | regulation of cell cycle G2/M phase transition | system development | nitrogen compound metabolic process | reproductive process | ureteric bud development | multicellular organism development | spleen development | lipid metabolic process | embryonic hemopoiesis | kidney morphogenesis | regulation of ossification | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of neuron differentiation | regulation of gene expression | kidney epithelium development | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | positive regulation of cell cycle G2/M phase transition | biosynthetic process | aromatic compound biosynthetic process | mesonephric epithelium development | lipid biosynthetic process | endocrine system development | mesonephros development | proximal/distal pattern formation | chordate embryonic development | cell communication | regulation of cellular metabolic process | renal tubule development | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | renal system development | embryonic morphogenesis | regulation of mitotic cell cycle | nephron development | ureteric bud morphogenesis | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regionalization | gland development | tissue morphogenesis | branching morphogenesis of an epithelial tube | anatomical structure development | positive regulation of mitotic cell cycle phase transition | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | embryonic organ development | adrenal gland development | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | nephron morphogenesis | animal organ development | negative regulation of neuron differentiation | gene expression | transcription, DNA-templated | morphogenesis of a branching epithelium | steroid metabolic process | signaling | regulation of transcription, DNA-templated | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of nervous system development | regulation of developmental process | developmental process | positive regulation of cell cycle process | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | sex differentiation | negative regulation of cell development | nephron tubule development | negative regulation of cell differentiation | signal transduction | mesonephric tubule development | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

nuclear transcription factor complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular