QuickView for PDCD4 (gene)
- Gene Symbol:
- PDCD4
Homo sapiens - Full name:
- programmed cell death 4
- Synonyms:
- H731, programmed cell death protein 4, neoplastic transformation inhibitor protein, nuclear antigen H731, programmed cell death 4 (neoplastic transformation inhibitor), protein 197/15a
- Genomic Location:
- Chr 10: 112621586-112649754
- Description:
-
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-145 , Predicted Gene Targets for miR-15 , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-183 , Predicted Gene Targets for miR-141 , Predicted Gene Targets for miR-21 , Predicted Gene Targets for miR-23 , Predicted Gene Targets for miR-320 , Predicted Gene Targets for miR-330
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
10q25.2
GO Molecular Function
nucleic acid binding | organic cyclic compound binding | protein binding | heterocyclic compound binding | RNA binding
GO Biological Process
regulation of JUN kinase activity | negative regulation of JNK cascade | negative regulation of phosphorylation | negative regulation of MAPK cascade | negative regulation of cytokine production involved in inflammatory response | response to cytokine | response to lipopolysaccharide | positive regulation of apoptotic process | regulation of programmed cell death | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | cell differentiation | epithelial to mesenchymal transition | negative regulation of protein phosphorylation | epicardium-derived cardiac fibroblast cell development | cardiac cell development | mesenchyme development | negative regulation of stress-activated protein kinase signaling cascade | cellular process | negative regulation of inflammatory response | heart morphogenesis | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | regulation of cell cycle | response to growth factor | negative regulation of myofibroblast differentiation | positive regulation of muscle cell apoptotic process | positive regulation of epithelial cell apoptotic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | cellular response to molecule of bacterial origin | regulation of vasculature development | response to stimulus | positive regulation of NIK/NF-kappaB signaling | positive regulation of smooth muscle cell apoptotic process | negative regulation of protein kinase activity | regulation of cell proliferation | programmed cell death | positive regulation of endothelial cell apoptotic process | response to molecule of bacterial origin | negative regulation of metabolic process | response to interleukin-12 | interleukin-12-mediated signaling pathway | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to BMP | apoptotic process | response to external biotic stimulus | system development | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | regulation of MAPK cascade | positive regulation of inflammatory response | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | cardiac epithelial to mesenchymal transition | regulation of gene expression | response to lipid | negative regulation of cytokine production | regulation of smooth muscle cell differentiation | animal organ morphogenesis | negative regulation of smooth muscle cell proliferation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | cardiocyte differentiation | negative regulation of protein serine/threonine kinase activity | regulation of transcription by RNA polymerase II | regulation of endothelial cell apoptotic process | regulation of smooth muscle cell apoptotic process | negative regulation of smooth muscle cell differentiation | cellular response to cytokine stimulus | regulation of cytokine production involved in inflammatory response | regulation of cellular protein metabolic process | negative regulation of stress-activated MAPK cascade | regulation of epithelial cell apoptotic process | response to bacterium | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | heart development | regulation of protein phosphorylation | negative regulation of MAP kinase activity | regulation of RNA metabolic process | negative regulation of vascular smooth muscle cell proliferation | cell aging | response to organic substance | regulation of kinase activity | negative regulation of JUN kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | mesenchymal cell differentiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | positive regulation of cell death | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | positive regulation of programmed cell death | regulation of phosphate metabolic process | negative regulation of vascular smooth muscle cell differentiation | regulation of JNK cascade | negative regulation of cell cycle | negative regulation of protein metabolic process | BMP signaling pathway | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell development | regulation of cytokine production | anatomical structure morphogenesis | response to biotic stimulus | regulation of developmental process | developmental process | regulation of muscle cell differentiation | epithelial to mesenchymal transition involved in cardiac fibroblast development | negative regulation of cell proliferation | negative regulation of vasculature development | positive regulation of vascular associated smooth muscle cell apoptotic process | negative regulation of muscle cell differentiation | cellular response to BMP stimulus | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | negative regulation of cell death | circulatory system development | regulation of inflammatory response | aging | negative regulation of cell differentiation | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | cytosol | intracellular
