QuickView for PDE10A (gene)
- Gene Symbol:
- PDE10A
Homo sapiens - Full name:
- phosphodiesterase 10A
- Synonyms:
- ADSD2, HSPDE10A, IOLOD, LINC00473, PDE10A19, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 3',5' cAMP/cGMP phosphodiesterase, dJ416F21.1 (phosphodiesterase 10A), phosphodiesterase 10A1 (PDE10A1), phosphodiesterase 10A7 (PDE10A7)
- Genomic Location:
- Chr 6: 165664519-165995574
- Description:
-
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficien...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
PAX2_01 , RP58_01 , EGR_Q6 , CTTTAAR_UNKNOWN , PTF1BETA_Q6 , RNGTGGGC_UNKNOWN , AP2REP_01 , WTTGKCTG_UNKNOWN , IK1_01 , CTTTGT_LEF1_Q2
- Cytogenetic Map:
-
6q27
GO Molecular Function
guanyl ribonucleotide binding | cyclic nucleotide binding | cation binding | cAMP binding | ribonucleotide binding | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | nucleotide binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | anion binding | adenyl nucleotide binding | cGMP binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | organic cyclic compound binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | metal ion binding | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | guanyl nucleotide binding | small molecule binding
GO Biological Process
purine ribonucleotide metabolic process | negative regulation of cGMP-mediated signaling | nucleoside phosphate catabolic process | negative regulation of cellular process | organophosphate catabolic process | cellular process | organic substance catabolic process | nucleotide metabolic process | negative regulation of signaling | carbohydrate derivative catabolic process | ribose phosphate metabolic process | ribonucleotide metabolic process | regulation of cellular process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | purine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | G-protein coupled receptor signaling pathway | cellular biosynthetic process | nucleobase-containing compound catabolic process | nitrogen compound metabolic process | regulation of signal transduction | phosphorus metabolic process | cyclic nucleotide metabolic process | regulation of cGMP-mediated signaling | organophosphate metabolic process | small molecule metabolic process | cGMP metabolic process | cAMP catabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | nucleotide catabolic process | phosphate-containing compound metabolic process | cell communication | aromatic compound catabolic process | regulation of cAMP-mediated signaling | cyclic nucleotide catabolic process | cAMP metabolic process | cGMP catabolic process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of protein kinase A signaling | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | negative regulation of cAMP-mediated signaling | carbohydrate derivative metabolic process | heterocycle metabolic process | purine ribonucleotide catabolic process | cellular metabolic process | signal transduction | regulation of signaling | purine nucleotide catabolic process
GO Cellular Component
somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | perikaryon | cytosol | intracellular | membrane
