QuickView for PDE11A;jsessionid=4F3E745D2C96C6B4BDABA79C73C35308 (gene)

Gene Symbol:

PDE11A Homo sapiens

Full name:

phosphodiesterase 11A

Synonyms:

PPNAD2, dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP cyclic nucleotide phosphodiesterase 11A

Genomic Location:

Chr 2: 178196223-178681312

Description:

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of t...

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The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTGA_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  GGGYGTGNY_UNKNOWN ,  CAGGTG_E12_Q6 ,  AREB6_03

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-9

Cytogenetic Map:

2q31.2

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