QuickView for PDE2A (gene)

GO Molecular Function

guanyl ribonucleotide binding | cyclic nucleotide binding | cation binding | passive transmembrane transporter activity | cAMP binding | ribonucleotide binding | transmembrane transporter activity | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | nucleotide binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | protein domain specific binding | anion binding | adenyl nucleotide binding | cGMP binding | cation transmembrane transporter activity | purine nucleotide binding | transporter activity | hydrolase activity, acting on ester bonds | calcium ion transmembrane transporter activity | identical protein binding | ion transmembrane transporter activity | TPR domain binding | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | metal ion transmembrane transporter activity | protein dimerization activity | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | cation channel activity | inorganic cation transmembrane transporter activity | purine ribonucleotide binding | adenyl ribonucleotide binding | channel activity | drug binding | calcium channel activity | metal ion binding | ion channel activity | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | substrate-specific channel activity | guanyl nucleotide binding | small molecule binding

GO Biological Process

purine ribonucleotide metabolic process | negative regulation of intracellular transport | regulation of intracellular protein transport | response to cytokine | nucleoside phosphate catabolic process | response to cGMP | regulation of cellular localization | intracellular signal transduction | endothelial cell development | regulation of localization | establishment of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | regulation of protein import | cell differentiation | endothelial cell differentiation | response to drug | organophosphate catabolic process | response to organophosphorus | cellular process | organic substance catabolic process | localization | passive transmembrane transporter activity | nucleotide metabolic process | negative regulation of protein import into nucleus | negative regulation of signaling | metal ion transport | carbohydrate derivative catabolic process | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | response to growth factor | ribonucleotide metabolic process | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | tissue development | regulation of cellular process | regulation of metabolic process | catabolic process | transmembrane transporter activity | organic cyclic compound metabolic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | negative regulation of protein localization to nucleus | response to transforming growth factor beta | response to stimulus | negative regulation of protein transport | purine nucleotide metabolic process | regulation of cellular protein localization | cellular response to mechanical stimulus | cellular response to xenobiotic stimulus | negative regulation of intracellular protein transport | cellular nitrogen compound biosynthetic process | epithelial cell development | divalent metal ion transport | cellular nitrogen compound metabolic process | negative regulation of transport | cellular response to organic cyclic compound | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of peptide transport | cellular biosynthetic process | nucleobase-containing compound catabolic process | regulation of intracellular transport | regulation of nucleic acid-templated transcription | response to nitrogen compound | nitrogen compound metabolic process | regulation of signal transduction | endothelium development | calcium ion transmembrane transport | cGMP-mediated signaling | phosphorus metabolic process | response to purine-containing compound | positive regulation of inflammatory response | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | cellular response to 2,3,7,8-tetrachlorodibenzodioxine | cyclic nucleotide metabolic process | negative regulation of cellular protein localization | ion transmembrane transport | regulation of gene expression | cation transmembrane transporter activity | organophosphate metabolic process | regulation of protein import into nucleus, translocation | establishment of endothelial barrier | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | small molecule metabolic process | regulation of vascular permeability | cGMP metabolic process | regulation of transcription by RNA polymerase II | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | nucleobase-containing small molecule metabolic process | second-messenger-mediated signaling | cellular response to cytokine stimulus | biosynthetic process | aromatic compound biosynthetic process | nucleotide catabolic process | response to xenobiotic stimulus | phosphate-containing compound metabolic process | cellular response to drug | cell communication | regulation of cellular metabolic process | cyclic-nucleotide-mediated signaling | aromatic compound catabolic process | regulation of cAMP-mediated signaling | regulation of RNA metabolic process | regulation of nucleocytoplasmic transport | cellular response to transforming growth factor beta stimulus | cation transmembrane transport | cyclic nucleotide catabolic process | regulation of establishment of protein localization | response to organic substance | cGMP catabolic process | regulation of protein import into nucleus | cAMP-mediated signaling | response to mechanical stimulus | negative regulation of protein import into nucleus, translocation | metal ion transmembrane transporter activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | positive regulation of vascular permeability | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | calcium ion transport | cellular response to cGMP | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | cellular response to cAMP | inorganic cation transmembrane transport | negative regulation of vascular permeability | response to cAMP | cation channel activity | organonitrogen compound catabolic process | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | negative regulation of signal transduction | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | cation transport | channel activity | developmental process | calcium channel activity | negative regulation of cAMP-mediated signaling | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | regulation of transport | response to organonitrogen compound | epithelial cell differentiation | heterocycle metabolic process | ion channel activity | cellular response to macrophage colony-stimulating factor stimulus | purine ribonucleotide catabolic process | ion transport | response to 2,3,7,8-tetrachlorodibenzodioxine | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of inflammatory response | substrate-specific channel activity | signal transduction | regulation of signaling | purine nucleotide catabolic process | cellular response to growth factor stimulus | multicellular organismal process

GO Cellular Component

presynaptic membrane | mitochondrial matrix | organelle inner membrane | intracellular membrane-bounded organelle | synapse | mitochondrial inner membrane | organelle membrane | cell | organelle outer membrane | synaptic membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | presynapse | Golgi apparatus | endomembrane system | plasma membrane | perinuclear region of cytoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | mitochondrial envelope | cell periphery | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular | membrane

PATHWAYS

REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | REACTOME_PLATELET_HOMEOSTASIS | REACTOME_CGMP_EFFECTS | REACTOME_SIGNALING_BY_GPCR | REACTOME_HEMOSTASIS | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | REACTOME_GPCR_DOWNSTREAM_SIGNALING

PROTEIN FAMILY

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | GAF domain | HD/PDEase domain | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | GAF-like domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily