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QuickView for PDE3A (gene)

Gene Symbol:
PDE3A Homo sapiens Homo sapiens
Full name:
phosphodiesterase 3A
CGI-PDE, CGI-PDE A, CGI-PDE-A, HTNB, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, cAMP phosphodiesterase, myocardial cGMP-inhibited, cyclic GMP-inhibited phosphodiesterase A, phosphodiesterase 3A, cGMP-inhibited
Genomic Location:
Chr 12: 20413464-20725148
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays ...
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Danio rerio Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12

GO Molecular Function

cation binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | cyclic-nucleotide phosphodiesterase activity | catalytic activity | hydrolase activity, acting on ester bonds | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | metal ion binding | 3',5'-cyclic-nucleotide phosphodiesterase activity

GO Biological Process

regulation of cell cycle process | response to cGMP | developmental process involved in reproduction | intracellular signal transduction | regulation of cell development | regulation of programmed cell death | regulation of oogenesis | regulation of meiotic cell cycle | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | response to drug | regulation of organelle organization | regulation of oocyte development | response to organophosphorus | cellular process | cell maturation | negative regulation of signaling | multicellular organismal reproductive process | negative regulation of apoptotic process | regulation of cell cycle | response to growth factor | regulation of cell differentiation | gamete generation | regulation of cellular process | regulation of apoptotic process | cellular response to organonitrogen compound | positive regulation of oogenesis | response to transforming growth factor beta | response to stimulus | female gamete generation | germ cell development | reproduction | cellular response to organic cyclic compound | blood circulation | G-protein coupled receptor signaling pathway | response to nitrogen compound | reproductive process | regulation of signal transduction | cGMP-mediated signaling | response to purine-containing compound | lipid metabolic process | oocyte differentiation | regulation of vascular permeability | oogenesis | positive regulation of cell differentiation | second-messenger-mediated signaling | cell communication | cyclic-nucleotide-mediated signaling | regulation of cAMP-mediated signaling | cellular response to transforming growth factor beta stimulus | multicellular organism reproduction | response to organic substance | regulation of meiotic nuclear division | cAMP-mediated signaling | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | positive regulation of vascular permeability | anatomical structure development | metabolic process | positive regulation of cell development | developmental maturation | negative regulation of programmed cell death | cellular response to cGMP | organic substance metabolic process | negative regulation of vascular permeability | oocyte development | regulation of cell communication | negative regulation of signal transduction | signaling | response to organic cyclic compound | cell development | regulation of developmental process | developmental process | negative regulation of cAMP-mediated signaling | response to organonitrogen compound | oocyte maturation | cellular response to organic substance | positive regulation of oocyte development | regulation of cell death | negative regulation of cell death | sexual reproduction | regulation of cellular component organization | signal transduction | regulation of signaling | cellular response to growth factor stimulus | multicellular organismal process

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | cytoplasm | cytosol | intracellular | membrane