QuickView for PDE4 (gene)

Gene Symbol:

PDE4A Homo sapiens

Full name:

phosphodiesterase 4A

Synonyms:

DPDE2, PDE4, PDE46, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, phosphodiesterase 4A, cAMP-specific (dunce, phosphodiesterase E2 dunce homolog, Drosophila, phosphodiesterase isozyme 4

Genomic Location:

Chr 19: 10424637-10441306

Description:

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in m...

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The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACTGTAG_MIR139 ,  AAGCCAT_MIR135A_MIR135B ,  GTACTGT_MIR101 ,  AAGCAAT_MIR137 ,  TGCCTTA_MIR124A ,  AAGGGAT_MIR188 ,  AGGAAGC_MIR5163P ,  CTCCAAG_MIR432

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-188

Cytogenetic Map:

19p13.2

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