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QuickView for PDE4A (gene)

Gene Symbol:
PDE4A Homo sapiens Homo sapiens
Full name:
phosphodiesterase 4A
DPDE2, PDE4, PDE46, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, phosphodiesterase 4A, cAMP-specific (dunce, phosphodiesterase E2 dunce homolog, Drosophila, phosphodiesterase isozyme 4
Genomic Location:
Chr 19: 10424637-10441306
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in m...
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 19

GO Molecular Function

cyclic nucleotide binding | cation binding | cAMP binding | ribonucleotide binding | nucleotide binding | 3',5'-cyclic-AMP phosphodiesterase activity | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | catalytic activity | anion binding | adenyl nucleotide binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | ion binding | organic cyclic compound binding | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | metal ion binding | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | small molecule binding

GO Biological Process

purine ribonucleotide metabolic process | nucleoside phosphate catabolic process | response to drug | organophosphate catabolic process | cellular process | organic substance catabolic process | nucleotide metabolic process | carbohydrate derivative catabolic process | ribose phosphate metabolic process | ribonucleotide metabolic process | regulation of cellular process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | purine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | G-protein coupled receptor signaling pathway | cellular biosynthetic process | nucleobase-containing compound catabolic process | nitrogen compound metabolic process | regulation of signal transduction | phosphorus metabolic process | cyclic nucleotide metabolic process | nervous system process | organophosphate metabolic process | small molecule metabolic process | cAMP catabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | nucleotide catabolic process | phosphate-containing compound metabolic process | cellular response to drug | cell communication | aromatic compound catabolic process | regulation of cAMP-mediated signaling | cyclic nucleotide catabolic process | cAMP metabolic process | regulation of intracellular signal transduction | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of protein kinase A signaling | sensory perception | organonitrogen compound catabolic process | regulation of cell communication | signaling | sensory perception of chemical stimulus | carbohydrate derivative metabolic process | heterocycle metabolic process | purine ribonucleotide catabolic process | cellular metabolic process | sensory perception of smell | signal transduction | regulation of signaling | purine nucleotide catabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | ruffle | cell projection membrane | cell | nuclear lumen | ruffle membrane | cytoplasm | intracellular organelle | leading edge membrane | cell projection | nucleoplasm | plasma membrane | cell leading edge | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane