QuickView for PDE6H;jsessionid=4F3E745D2C96C6B4BDABA79C73C35308 (gene)
- Gene Symbol:
- PDE6H
Homo sapiens - Full name:
- phosphodiesterase 6H
- Synonyms:
- ACHM6, RCD3, retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, GMP-PDE gamma, phosphodiesterase 6H, cGMP-specific, cone, gamma
- Genomic Location:
- Chr 12: 15017245-15026066
- Description:
-
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Danio rerio , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
12p12.3
GO Molecular Function
guanyl ribonucleotide binding | cyclic nucleotide binding | ribonucleotide binding | nucleotide binding | enzyme inhibitor activity | hydrolase activity | carbohydrate derivative binding | cyclic-nucleotide phosphodiesterase activity | molecular function regulator | catalytic activity | anion binding | cGMP binding | purine nucleotide binding | hydrolase activity, acting on ester bonds | 3',5'-cyclic-GMP phosphodiesterase activity | ion binding | organic cyclic compound binding | protein binding | phosphoric diester hydrolase activity | phosphoric ester hydrolase activity | purine ribonucleotide binding | enzyme regulator activity | heterocyclic compound binding | 3',5'-cyclic-nucleotide phosphodiesterase activity | guanyl nucleotide binding | small molecule binding
GO Biological Process
regulation of MAP kinase activity | positive regulation of phosphate metabolic process | positive regulation of protein kinase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | response to stimulus | enzyme inhibitor activity | positive regulation of protein metabolic process | positive regulation of protein serine/threonine kinase activity | activation of protein kinase activity | positive regulation of ERBB signaling pathway | molecular function regulator | regulation of signal transduction | negative regulation of catalytic activity | regulation of MAPK cascade | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | nervous system process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | regulation of cellular protein metabolic process | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | positive regulation of molecular function | activation of MAPK activity | positive regulation of protein modification process | regulation of kinase activity | regulation of intracellular signal transduction | visual perception | regulation of epidermal growth factor receptor signaling pathway | sensory perception of light stimulus | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of MAPK cascade | sensory perception | regulation of cell communication | negative regulation of molecular function | regulation of ERBB signaling pathway | positive regulation of phosphorylation | enzyme regulator activity | positive regulation of epidermal growth factor receptor signaling pathway | positive regulation of MAP kinase activity | regulation of G-protein coupled receptor protein signaling pathway | positive regulation of metabolic process | positive regulation of signaling | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
