QuickView for PDGFA (gene)

Gene Symbol:

PDGFA Homo sapiens

Full name:

platelet derived growth factor subunit A

Synonyms:

PDGF-A, PDGF1, platelet-derived growth factor subunit A, PDGF A-chain, PDGF subunit A, platelet-derived growth factor A-chain, platelet-derived growth factor alpha chain, platelet-derived growth factor alpha polypeptide

Genomic Location:

Chr 7: 503421-526007

Description:

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-deri...

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This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  HEN1_01 ,  YTATTTTNR_MEF2_02 ,  CTTTGA_LEF1_Q2 ,  TGAYRTCA_ATF3_Q6 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  TST1_01 ,  PITX2_Q2 ,  AREB6_03 ,  POU3F2_02 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  ATF1_Q6 ,  GATA1_05 ,  CDC5_01 ,  ACAWYAAAG_UNKNOWN ,  TGACATY_UNKNOWN

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Cytogenetic Map:

7p22.3

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