QuickView for PDGFB;jsessionid=7FD6C2E098A6C878FD14A9B37CF184FB (gene)

Gene Symbol:

PDGFB Homo sapiens

Full name:

platelet derived growth factor subunit B

Synonyms:

IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet-derived growth factor subunit B, PDGF subunit B, PDGF, B chain, becaplermin, platelet-derived growth factor 2, platelet-derived growth factor B chain, platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog), platelet-derived growth factor, beta polypeptide (oncogene SIS), proto-oncogene c-Sis

Genomic Location:

Chr 22: 37949665-37970936

Description:

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-deri...

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This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  CMYB_01 ,  HNF4ALPHA_Q6 ,  SMTTTTGT_UNKNOWN ,  PR_02 ,  CEBPA_01 ,  DR3_Q4 ,  TAL1ALPHAE47_01 ,  ETS_Q4 ,  TCANNTGAY_SREBP1_01 ,  ZIC1_01 ,  RYTTCCTG_ETS2_B ,  ARNT_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  NFAT_Q6 ,  HEN1_01 ,  PR_01 ,  GCANCTGNY_MYOD_Q6 ,  NGFIC_01 ,  CIZ_01 ,  ARP1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  AP2GAMMA_01 ,  SREBP1_Q6 ,  GR_Q6_01 ,  E2A_Q2 ,  COUP_01 ,  AP2ALPHA_01 ,  MYCMAX_B ,  EGR2_01 ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  CAGGTA_AREB6_01 ,  RP58_01 ,  CAGGTG_E12_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TTCYRGAA_UNKNOWN ,  EGR_Q6 ,  AP2_Q6_01 ,  MYOD_Q6 ,  GGGCGGR_SP1_Q6 ,  AREB6_01 ,  CEBPB_02 ,  HIF1_Q5 ,  RAAGNYNNCTTY_UNKNOWN ,  E47_01 ,  GCM_Q2 ,  AP2_Q3 ,  GCCNNNWTAAR_UNKNOWN ,  HSF2_01 ,  AHRARNT_01 ,  RNGTGGGC_UNKNOWN ,  AP2_Q6 ,  CEBP_Q3 ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  AAAYRNCTG_UNKNOWN ,  ARGGGTTAA_UNKNOWN ,  HEN1_02 ,  CTGCAGY_UNKNOWN ,  GTGGGTGK_UNKNOWN ,  TAL1BETAITF2_01 ,  EGR1_01 ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  SMAD_Q6 ,  ZF5_B ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  ER_Q6 ,  DR4_Q2 ,  ETS1_B ,  PPARA_02 ,  HIF1_Q3 ,  EGR3_01 ,  PAX4_01 ,  GGGTGGRR_PAX4_03 ,  TCF11MAFG_01 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

22q13.1

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