QuickView for PDGFRA;jsessionid=7D1D703D6C2B949600F429147F686899 (gene)

Gene Symbol:

PDGFRA Homo sapiens

Full name:

platelet derived growth factor receptor alpha

Synonyms:

CD140A, PDGFR-2, PDGFR2, platelet-derived growth factor receptor alpha, CD140 antigen-like family member A, CD140a antigen, PDGF-R-alpha, alpha-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 2, platelet-derived growth factor receptor, alpha polypeptide

Genomic Location:

Chr 4: 54790204-54859169

Description:

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-der...

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This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  HNF4ALPHA_Q6 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TGIF_01 ,  TGANTCA_AP1_C ,  HNF1_01 ,  RYTTCCTG_ETS2_B ,  RSRFC4_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  GATA_Q6 ,  YTATTTTNR_MEF2_02 ,  CTACTGT_MIR199A ,  TGTGTGA_MIR377 ,  GTGACTT_MIR224 ,  RSRFC4_Q2 ,  TACTTGA_MIR26A_MIR26B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  MAF_Q6 ,  GATA1_04 ,  ACTGTGA_MIR27A_MIR27B ,  TAAWWATAG_RSRFC4_Q2 ,  GTGTGAG_MIR342 ,  CEBP_Q2 ,  TTGGAGA_MIR5155P_MIR519E ,  TITF1_Q3 ,  CAGGTA_AREB6_01 ,  MEF2_01 ,  CAGGTG_E12_Q6 ,  NKX62_Q2 ,  ACTACCT_MIR196A_MIR196B ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  GACAATC_MIR219 ,  CEBPB_02 ,  ACTGCCT_MIR34B ,  YKACATTT_UNKNOWN ,  GATA6_01 ,  OCT1_03 ,  NKX61_01 ,  CTTTAAR_UNKNOWN ,  PAX6_01 ,  HFH4_01 ,  TGTTTGY_HNF3_Q6 ,  E2F_03 ,  GATA1_02 ,  YCATTAA_UNKNOWN ,  GATA2_01 ,  EN1_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  CEBP_C ,  AAAYRNCTG_UNKNOWN ,  CART1_01 ,  AFP1_Q6 ,  GAGCCAG_MIR149 ,  CTGAGCC_MIR24 ,  SMAD4_Q6 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CCCNNNNNNAAGWT_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  AAACCAC_MIR140 ,  TCCCCAC_MIR491 ,  TGACATY_UNKNOWN ,  GTTAAAG_MIR302B ,  HNF1_Q6 ,  CEBPGAMMA_Q6 ,  CAATGCA_MIR33 ,  HNF6_Q6 ,  AAGCACA_MIR218 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-140 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-491 ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-496

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Cytogenetic Map:

4q12

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