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QuickView for PDK1 (gene)


Gene Symbol:
PDK1 Homo sapiens Homo sapiens
Full name:
pyruvate dehydrogenase kinase 1
Synonyms:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial, PDH kinase 1, mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1, pyruvate dehydrogenase kinase, isoenzyme 1
Genomic Location:
Chr 2: 173129025-173172108
Description:
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a spe...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2
2q31.1





GO Molecular Function

ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | pyruvate dehydrogenase (acetyl-transferring) kinase activity | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding

GO Biological Process

cellular response to decreased oxygen levels | intracellular signal transduction | regulation of carbohydrate metabolic process | glucose metabolic process | cellular process | response to hypoxia | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | response to stimulus | cellular response to hypoxia | response to stress | programmed cell death | protein modification process | macromolecule modification | apoptotic process | response to oxygen levels | nitrogen compound metabolic process | pyruvate dehydrogenase (acetyl-transferring) kinase activity | phosphorus metabolic process | cellular response to oxidative stress | cellular response to stress | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | response to oxidative stress | regulation of fatty acid metabolic process | cell proliferation | phosphorylation | carbohydrate metabolic process | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | apoptotic signaling pathway | intrinsic apoptotic signaling pathway in response to oxidative stress | hypoxia-inducible factor-1alpha signaling pathway | protein metabolic process | regulation of acetyl-CoA biosynthetic process from pyruvate | regulation of glucose metabolic process | metabolic process | hexose metabolic process | protein kinase activity | organic substance metabolic process | cell death | regulation of phosphate metabolic process | regulation of acyl-CoA biosynthetic process | signaling | cellular protein metabolic process | regulation of cellular ketone metabolic process | cell death in response to oxidative stress | kinase activity | cellular protein modification process | regulation of lipid metabolic process | cellular metabolic process | signal transduction | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

mitochondrial matrix | intracellular membrane-bounded organelle | catalytic complex | cell | oxidoreductase complex | nuclear lumen | pyruvate dehydrogenase complex | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | mitochondrial pyruvate dehydrogenase complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular