QuickView for PDK2 (gene)
- Gene Symbol:
- PDK2
Homo sapiens - Full name:
- pyruvate dehydrogenase kinase 2
- Synonyms:
- PDHK2, PDKII, pyruvate dehydrogenase kinase, isozyme 2, PDH kinase 2, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial, pyruvate dehydrogenase kinase, isoenzyme 2, pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
- Genomic Location:
- Chr 17: 45527695-45543422
- Description:
-
This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isof...
- Orthologs:
- Mus musculus , Rattus norvegicus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
17q21.33
GO Molecular Function
ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | pyruvate dehydrogenase (acetyl-transferring) kinase activity | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
response to extracellular stimulus | response to nutrient levels | intracellular signal transduction | regulation of carbohydrate metabolic process | response to hormone | glucose metabolic process | cellular response to extracellular stimulus | glucose homeostasis | cellular process | regulation of calcium-mediated signaling | response to peptide hormone | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | cellular response to organonitrogen compound | response to stimulus | response to stress | response to peptide | programmed cell death | protein modification process | macromolecule modification | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | pyruvate dehydrogenase (acetyl-transferring) kinase activity | cellular response to peptide hormone stimulus | phosphorus metabolic process | cellular response to insulin stimulus | cellular response to oxidative stress | cellular response to stress | cellular response to peptide | insulin receptor signaling pathway | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | monosaccharide metabolic process | small molecule metabolic process | response to nutrient | response to oxidative stress | regulation of fatty acid metabolic process | phosphorylation | carbohydrate metabolic process | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | homeostatic process | apoptotic signaling pathway | protein metabolic process | cellular response to nutrient | response to organic substance | regulation of pH | regulation of acetyl-CoA biosynthetic process from pyruvate | regulation of intracellular signal transduction | response to insulin | cell surface receptor signaling pathway | regulation of glucose metabolic process | metabolic process | hexose metabolic process | chemical homeostasis | protein kinase activity | cellular response to reactive oxygen species | organic substance metabolic process | cell death | response to reactive oxygen species | ion homeostasis | regulation of phosphate metabolic process | intrinsic apoptotic signaling pathway by p53 class mediator | regulation of acyl-CoA biosynthetic process | regulation of cell communication | signaling | cellular protein metabolic process | regulation of cellular ketone metabolic process | kinase activity | cellular protein modification process | response to organonitrogen compound | regulation of gluconeogenesis | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | cellular metabolic process | cellular response to organic substance | signal transduction by p53 class mediator | carbohydrate homeostasis | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | catalytic complex | cell | oxidoreductase complex | nuclear lumen | pyruvate dehydrogenase complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | mitochondrial pyruvate dehydrogenase complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
