QuickView for PDPK1 (gene)
- Gene Symbol:
- PDPK1
Homo sapiens - Full name:
- 3-phosphoinositide dependent protein kinase 1
- Synonyms:
- PDK1, PDPK2, PDPK2P, PRO0461, 3-phosphoinositide-dependent protein kinase 1, 3-phosphoinositide-dependent protein kinase 2 pseudogene, PkB kinase like gene 1
- Genomic Location:
- Chr 16: 2527971-2593190
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-128 , Predicted Gene Targets for miR-200b , Predicted Gene Targets for miR-223 , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-33 , Predicted Gene Targets for miR-369-3p , Predicted Gene Targets for miR-382 , Predicted Gene Targets for miR-140 , Predicted Gene Targets for miR-374 , Predicted Gene Targets for miR-375
- Cytogenetic Map:
-
16p13.3
GO Molecular Function
kinase binding | enzyme activator activity | lipase activator activity | protein kinase binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | insulin receptor binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | phospholipase activator activity | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | kinase activity | phospholipase binding | heterocyclic compound binding | 3-phosphoinositide-dependent protein kinase activity | small molecule binding
GO Biological Process
positive regulation of immune response | RNA metabolic process | positive regulation of release of sequestered calcium ion into cytosol | negative regulation of phosphorylation | positive regulation of locomotion | negative regulation of immune system process | actin filament-based process | hyperosmotic response | cell motility | immune response-regulating signaling pathway | regulation of cellular localization | intracellular signal transduction | enzyme activator activity | regulation of localization | cell-substrate adhesion | regulation of programmed cell death | peptidyl-amino acid modification | actin cytoskeleton organization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of neuron death | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | positive regulation of lymphocyte activation | regulation of protein localization to membrane | regulation of cardiac muscle cell apoptotic process | cell differentiation | immune response-activating cell surface receptor signaling pathway | positive regulation of epithelial cell proliferation | T cell receptor signaling pathway | adherens junction assembly | lymphocyte costimulation | type B pancreatic cell differentiation | regulation of sprouting angiogenesis | negative regulation of protein phosphorylation | cellular chemical homeostasis | lipase activator activity | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | innate immune response activating cell surface receptor signaling pathway | regulation of neuron death | focal adhesion assembly | innate immune response-activating signal transduction | cellular process | regulation of cell motility | localization | cellular homeostasis | extrinsic apoptotic signaling pathway | type B pancreatic cell development | negative regulation of signaling | positive regulation of immune effector process | cell-substrate adherens junction assembly | positive regulation of protein kinase activity | hemostasis | glandular epithelial cell differentiation | negative regulation of apoptotic process | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | cell junction assembly | regulation of angiogenesis | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | response to nerve growth factor | epidermal growth factor receptor signaling pathway | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | endocrine pancreas development | cellular component organization | regulation of mast cell degranulation | calcium ion homeostasis | negative regulation of toll-like receptor signaling pathway | positive regulation of epithelial cell migration | regulation of vasculature development | response to stimulus | negative regulation of epithelial cell apoptotic process | peptidyl-threonine phosphorylation | positive regulation of vascular endothelial cell proliferation | regulation of cellular protein localization | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | positive regulation of cation transmembrane transport | negative regulation of protein kinase activity | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | response to peptide | positive regulation of cell-cell adhesion | epithelial cell development | protein serine/threonine kinase activity | programmed cell death | positive regulation of cell activation | activation of innate immune response | positive regulation of sprouting angiogenesis | cellular nitrogen compound metabolic process | positive regulation of lipase activity | positive regulation of T cell activation | immune response-activating signal transduction | positive regulation of blood vessel endothelial cell migration | ERBB signaling pathway | negative regulation of metabolic process | cellular component assembly | protein modification process | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | activation of protein kinase activity | regulation of intracellular transport | molecular function regulator | metal ion homeostasis | blood coagulation | regulation of nucleic acid-templated transcription | negative regulation of cellular response to transforming growth factor beta stimulus | locomotion | response to nitrogen compound | negative regulation of neuron apoptotic process | apoptotic process | regulation of calcium ion transport into cytosol | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | enteroendocrine cell differentiation | regulation of signal transduction | negative regulation of phosphate metabolic process | positive regulation of calcium ion transmembrane transport | adherens junction organization | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of toll-like receptor signaling pathway | cellular response to peptide hormone stimulus | phosphorus metabolic process | negative regulation of striated muscle cell apoptotic process | cellular response to insulin stimulus | regulation of catalytic activity | cellular response to nerve growth factor stimulus | regulation of phosphorylation | wound healing | regulation of T cell activation | positive regulation of protein localization to plasma membrane | regulation of gene expression | platelet activation | pancreas development | cellular response to peptide | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | positive regulation of ion transmembrane transport | positive regulation of cytosolic calcium ion concentration | regulation of mast cell activation | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | negative regulation of cellular response to growth factor stimulus | cell-substrate junction assembly | regulation of cellular component movement | regulation of endothelial cell apoptotic process | positive regulation of hydrolase activity | Fc-epsilon receptor signaling pathway | regulation of endothelial cell migration | second-messenger-mediated signaling | activation of protein kinase B activity | regulation of release of sequestered calcium ion into cytosol | positive regulation of cell migration | negative regulation of cardiac muscle cell apoptotic process | biosynthetic process | response to osmotic stress | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | glandular epithelial cell development | regulation of phospholipase activity | regulation of calcium ion transmembrane transport | endocrine system development | regulation of epithelial cell apoptotic process | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | regulation of muscle cell apoptotic process | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | regulation of protein metabolic process | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | regulation of cellular response to growth factor stimulus | coagulation | apoptotic signaling pathway | positive regulation of molecular function | calcium-mediated signaling | cellular response to epidermal growth factor stimulus | activation of immune response | protein metabolic process | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of kinase activity | response to wounding | regulation of intracellular signal transduction | regulation of exocytosis | response to insulin | anatomical structure development | cell surface receptor signaling pathway | metabolic process | regulation of protein localization to plasma membrane | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of body fluid levels | negative regulation of programmed cell death | regulation of vesicle-mediated transport | negative regulation of muscle cell apoptotic process | chemical homeostasis | regulation of secretion | cell adhesion | nucleobase-containing compound metabolic process | protein kinase activity | organic substance metabolic process | regulation of sequestering of calcium ion | cell death | animal organ development | positive regulation of ion transport | regulation of endothelial cell proliferation | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | cellular response to brain-derived neurotrophic factor stimulus | positive regulation of kinase activity | ion homeostasis | regulation of phosphate metabolic process | cytoskeleton organization | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | transcription, DNA-templated | regulation of regulated secretory pathway | positive regulation of phospholipase activity | positive regulation of endothelial cell migration | cell activation | response to epidermal growth factor | phospholipase activator activity | negative regulation of protein metabolic process | regulation of epithelial cell migration | T cell costimulation | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell-matrix adhesion | cell development | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | cellular macromolecule biosynthetic process | positive regulation of calcium ion transport into cytosol | regulation of developmental process | regulation of ion transport | kinase activity | developmental process | organelle organization | Fc receptor signaling pathway | peptidyl-serine phosphorylation | regulation of calcium ion transport | cellular protein modification process | columnar/cuboidal epithelial cell development | regulation of transport | regulation of cell-cell adhesion | response to organonitrogen compound | cellular metal ion homeostasis | epithelial cell differentiation | stimulatory C-type lectin receptor signaling pathway | heterocycle metabolic process | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | divalent inorganic cation homeostasis | positive regulation of leukocyte cell-cell adhesion | positive regulation of angiogenesis | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of calcium ion transport | 3-phosphoinositide-dependent protein kinase activity | signal transduction | regulation of signaling | negative regulation of endothelial cell apoptotic process | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | synapse | somatodendritic compartment | adherens junction | focal adhesion | cytoplasmic vesicle | cell body | cell | nuclear lumen | neuronal cell body | cytoplasm | cell-substrate junction | intracellular organelle | cell projection | postsynapse | nucleoplasm | plasma membrane | perikaryon | vesicle | postsynaptic density | asymmetric synapse | membrane-bounded organelle | nucleus | organelle | postsynaptic specialization | cell periphery | membrane-enclosed lumen | cell-substrate adherens junction | cytosol | intracellular vesicle | intracellular | cell junction | membrane
