QuickView for PE-2 (gene)
- Gene Symbol:
- ERF
Homo sapiens - Full name:
- ETS2 repressor factor
- Synonyms:
- CHYTS, CRS4, PE-2, PE2, ETS domain-containing transcription factor ERF
- Genomic Location:
- Chr 19: 47443557-47451149
- Description:
-
ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
PAX4_04 , STAT4_01 , PU1_Q6 , STAT1_02 , ATF6_01 , RYTTCCTG_ETS2_B , E2F1_Q4_01 , CACGTG_MYC_Q2 , STAT6_02 , E4BP4_01
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
19q13.2
GO Molecular Function
sequence-specific DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | nucleic acid binding | DNA binding | transcription corepressor activity | organic cyclic compound binding | DNA-binding transcription factor activity | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | cellular process | negative regulation of nucleic acid-templated transcription | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | cell cycle | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | DNA-binding transcription factor activity | mitotic cell cycle | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | developmental process | negative regulation of transcription by RNA polymerase II | transcription coregulator activity | heterocycle metabolic process | cellular metabolic process | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
