QuickView for PEDF (gene)

Gene Symbol:

SERPINF1 Homo sapiens

Full name:

serpin family F member 1

Synonyms:

EPC-1, OI12, OI6, PEDF, PIG35, pigment epithelium-derived factor, cell proliferation-inducing gene 35 protein, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, testis tissue sperm-binding protein Li 70n

Genomic Location:

Chr 17: 1612009-1627618

Description:

This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in th...

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This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYCMAX_B ,  YAATNRNNNYNATT_UNKNOWN ,  HNF4_01 ,  CEBPDELTA_Q6 ,  CEBPB_02 ,  CTTTAAR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  AP2REP_01 ,  CHOP_01 ,  CTGCAGY_UNKNOWN

Cytogenetic Map:

17p13.3

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